Background: Antimicrobial peptides (AMPs) are synthesized and secreted by immune and epithelial cells that are constantly exposed to environmental microbes. AMPs are essential for barrier defense and deficiencies lead to increased susceptibility to infection. In addition to their ability to disrupt the integrity of bacterial, viral and fungal membranes, AMPs...
The human cathelicidin antimicrobial peptide (CAMP) is a broad spectrum microbicidal agent and modulator of both the innate and adaptive immune system. It is induced by 1,25-dihydroxyvitamin D (1,25(OH)₂D₃) through activation of the vitamin D receptor (VDR) and primary bile salts through activation of the xenobiotic nuclear receptor farnesoid X...
The gut microbiome influences human disease including Type 2 diabetes, obesity and metabolic syndrome and interacts with the innate immune system. The human cathelicidin antimicrobial peptide (hCAMP), an important component of the innate immune system, and vitamin D and xanthohumol, a natural compound found in beer hops, regulate its expression....
The vitamin D receptor (VDR) mediates the pleiotropic biologic effects of 1alpha,25
dihydroxy-vitamin D3. Recent in vitro studies suggested that curcumin and poly-unsaturated fatty
acids (PUFAs) also bind to VDR with low affinity. As potential ligands for the VDR, we hypothesized
that curcumin and PUFAs would induce expression of known...
The temporal development of biological control of arthropod pests in perennial cropping
systems is largely unreported. In this study, the development of biological control of twospotted
spider mite, Tetranychus urticae Koch, and hop aphid, Phorodon humuli (Schrank), in a new planting
of hop in Oregon is described over a period...
Several studies were conducted to determine if a more consistent
predictor of phytotoxicity to winter oats could be obtained with a
surfactant-herbicide ratio or a per-unit-volume concentration of surfactant,
independent of volume. The herbicides tested were 2,2-dichloropropionic acid (dalapon), 1,1'-dimethyl-4, 4'-bipyridinium
(paraquat), and 3-tert-butyl-5-chloro-6-methyluracil (terbacil) with
the nonionic surfactant X-77...