Circadian clocks coordinate molecular, cellular, physiological, and behavioral processes with the 24-hour solar day. While clock functions are well understood in young animals, it is not clear how aging or neurodegenerative disease affects the various levels of the circadian system. A common symptom of many neurodegenerative diseases including Alzheimer’s disease...
This investigation is concerned with the determination of the temperature-effective period (T.E.P.) for crossvein development at physiological temperatures using three isogenic crossveinlesslike (cvl) lines of Drosophila melanogaster.
The method used to determine T.E.P. relies on temperature differences in phenotypes and on a program of transfers from one temperature to another...
The frequency of exchanges was measured in a reversed
acrocentric compound X chromosome that is deficient for interstitial
heterochromatin. Previous studies on similar chromosomes
containing interstitial heterochromatin have demonstrated a very
low frequency of single exchanges, and high frequencies of the
double and no exchange classes. It has been postulated...
Development of the posterior crossvein in crossveinless-like
strains of Drosophila melanogaster can be influenced by high temperature
shocks at specific times in pupal development.
Three sensitive periods were detected in age response studies
on Ona X, Ona II, 5-hi III; crossvein restoration at 14 hours in
pupal development, a crossvein...
Circadian clocks are endogenous molecular mechanisms that coordinate daily rhythms in gene expression, cellular activities, and physiological functions with external day/night cycles. Breakdown of circadian rhythms such as sleep/wake cycles is associated with the onset of several neurological diseases; however, it is not clear whether disruption of rhythms is a...
The fruitless (fru) gene in Drosophila melanogaster is a multifunctional gene having sex-specific functions in the regulation of male sexual behavior and sex-nonspecific functions affecting adult viability and external morphology. While much attention has focused on fru's sex-specific roles, little is known about its sex-nonspecific functions. The embryonic central nervous...
Courtship and copulation behaviors in Drosophila melanogaster males are regulated by sex-specific products from the gene fruitless (fru). Male-specific FRU proteins (FRU[superscript M]) are putative transcription factors of the BTB-ZnF family that likely act by controlling development and maintenance of the neural circuitry used during male sexual behavior. However, which...