Assay conditions and analytical methods established for the
study of epoxidation of the insecticides aldrin and heptachlor, by
rat liver microsomes have been employed to study the same reaction
catalyzed by trout liver microsomes. At 37° C and pH 8.0, rainbow
trout liver microsomes, incubated with 54.8 millimicromoles of
either...
The presence in rat liver microsomes of an enzyme system
which demethylates N-methylhydrazines and azo compounds to formaldehyde
has been reported. Some of the compounds found to be
substrates were monomethylhydrazine, N-isopropyl-α-(2-methylhydrazino)-
p-toluamide and the azo derivative of the latter hydrazine. This
enzyme can be classified as a mixed function...
This dissertation describes formulation of a gastric retention device (GRD) and sustained release (SR) hydrochlorothiazide beads at Oregon State University. Formulation condition and amounts of excipients had significant influence on characteristic of the GRD. The GRD containing SR hydrochlorothiazide beads was employed to assess bioavailability/bioequivalency study in healthy subjects. An...
The inhibition of mixed-function oxidase (MFO) activity by ethanol or acetaldehyde was examined in vivo by monitoring changes in salivary half-life of antipyrine or aminopyrine in adult male Sprague-Dawley rats. Ethanol (1-6 g/kg, po) or acetaldehyde (4-8 mmol/kg, ip) was administered 20 minutes prior to antipyrine (100 mg/kg, ip) or...