Heavy use of outdoor recreation areas in the United States
since World War II is endangering their quality. Demand made by a
rapidly growing population with rising personal incomes and increasing
leisure time is expected to grow 50 percent nationally and 146 percent in Oregon by 1975. In Oregon, population,...
This paper focuses on the explosive and controversial growth in finfish farming in general and salmon aquaculture in particular, and the response of Alaska policy makers to this emerging industry. It seeks to define and analyze why Alaska policy makers chose to prohibit all commercial culture of finfish at a...
The discovery of the methylerythritol phosphate pathway (the MEP pathway) as an alternate pathway for isoprenoid biosynthesis in some organisms including most bacteria, malarial parasites and plants, but not in animals, has stimulated extensive studies in this area. Research has revealed the potential of finding novel antibacterials, antimalarial drugs, and...
This dissertation details the investigation of an alternate pathway to
isoprenoids that occurs in plants and microorganisms, the non-mevalonate
pathway. This exploration of the pathway focuses on the second step, the
conversion of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methylerythritol-4-phosphate (MEP) by the enzyme DXP isomeroreductase (DXR). These studies led to an appreciation...
In recent years, the methyl erythritol phosphate (MEP) pathway to isoprenoids has been the subject of intensive research. The interest is because isoprenoids have important roles in many cellular processes essential for the survival of several pathogenic organisms, making the inhibition of this pathway an attractive target for the drug...