The binding of estrogen to endometrium and uterine arteries of the ewe was investigated by use of a [³H]estradiol exchange assay and by incubating whole tissue aliquants with [³ H]estradiol, a method which permits quantification of bound estrogen translocated from the cytoplasm to the nucleus. Five ewes were necropsied on...
The effects of estrogen treatment on uterine weight, uterine
nucleic acid content and adrenal weight were studied. Daily doses
of 0.05μg or 0.1 μg of Estradiol 17-β were administered subcutaneously
to seven day castrated female rats for periods varying
from 0 to 168 days. After two days of treatment uterine...
The effects of coumestrol on the uterine weight, uterine fluid
imbibition, uterine nucleic acid content, adrenal weight and body
weight of female rats were studied. Daily doses of 20 micrograms
of coumestrol per 0.1cc propylene glycol were administered subcutaneously
to spayed rats following a seven day recovery period,
for durations...
A total of five individual experiments were conducted with
gonadectomized, male sheep to study the influence of estrogen on
the plasma level of pituitary activities, with the greatest emphasis
given to gonadotropic activity. Estrogen treatments employed were
as follows:
1. 12 mg. diethylstilbestrol (DES) implanted subcutaneously.
2. 1 mg. DES...
The objective of the thesis was to determine the effects of
isolated coumestrol on the growth, carcass characteristics and
certain organs of wether lambs. The first of two trials was conducted
over an eight week period with two groups of heavy wether
lambs. Trial two was conducted over an 11...
Alfalfa accumulates phytoestrogens and when ingested binds the estrogen receptor and induces morphological changes similar to endogenous estrogens. The objective of this study is to evaluate morphological changes in uteri, vulva, and teats of ovariectomized prepubertal ewe lambs. Eighteen prepubertal ewe lambs were ovariectomized in November 2000 and fed nonestrogenic...
Osteoporosis is a common metabolic bone disease, affecting a third of women and a fifth of men over age 65. In the US, annual health care costs associated with osteoporosis are estimated to be over $20 billion. Osteoporosis is associated with increased fracture risk, which has been demonstrated to predict...