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Filtering by: Subject FK-506 (Drug) -- Synthesis

Part I : synthesis of azetidin-2-ones from pyrazolidin-3-ones ; Part II : synthesis of a subunit of the immunosuppressant FK-506

Creator:

Toske, Steven Gerald

Resource Type:

Dissertation

Full Text:

. Part II. Synthesis of the C20-C34 subunit 73 of the immunosuppressant drug FK-506 (1) was accomplished
Towards the Perfect Marriage Between Theory and Experiments in Drug Discovery and Synthesis : Insights into Structure Determination of Complex Natural Products and Mechanistic Understandings of Lactam Synthesis

Creator:

Snyder, Kevin M.

Abstract:

In this report, three studies are presented that aid in the development of drug discovery and their synthesis. In each, the importance of the marriage between computations and experiments is highlighted. Continued efforts in this vein are essential for future efforts towards improving human health. The first case study investigated...

Resource Type:

Masters Thesis

Full Text:

. Title: Towards the Perfect Marriage Between Theory and Experiments in Drug Discovery and Synthesis