Published March 1980. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
BCL11B, a gene regulatory transcription factor, is known to be a regulator of T cell development in the immune system, and has been identified as a tumor suppressor for T cell leukemias. Defining the molecular events that regulate the activity of BCL11B will provide potential drug targets that will aid...
Thymocytes, cells of the thymus gland, undergo developmental steps that
enable them to properly mature into T-cells. Errors in gene expression may lead to
improper maturation and potentially mass proliferation of dysfunctional thymocytes,
a hallmark of leukemia or lymphoma. BCL11B is a tumor suppressor and
transcriptional regulatory protein that is...
Phospholipase C-β (PLC-β) isozymes are key effectors in G protein-coupled
signaling pathways. Prior research suggested that some isoforms of PLC-β may exist
and function as dimers, but little is known about dimerization of PLC-β. Data from coimmunoprecipitation
assays of differentially-tagged PLC-β constructs and sizeexclusion
chromatography of native PLC-β support homodimerization...
The local and remote sources of variability of the South Atlantic Ocean are investigated using a set of numerical experiments and satellite data. A global, eddy-permitting, numerical simulation is analyzed to investigate the dynamical links between the Antarctic Circumpolar Current (ACC) and the Malvinas Current (MC). The model results indicate...
¹¹¹In/Cd perturbed angular correlation (PAC) gamma spectroscopy was used to
study the point defect thermodynamics of tetragonal zirconia (t-zirconia).
PAC can be used to measure, among other things, oxygen vacancy defect
concentrations in t-zirconia. Higher than expected concentrations of oxygen vacancies in
undoped samples were found using PAC. It was...
Nutrition and diet are significantly interrelated with oral health and disease.
The control of diet and nutrient intake and good oral hygiene are important elements
in the prevention and treatment of dental caries and periodontal disease.
Prevention of dental disease is the major focus of dentistry today, and dietary counseling...
The experiments explained in this Honors thesis are focused on finding a cellular model for analyzing Bcl11b, a transcription factor dysregulated in 20% of cases of T-cell Acute Lymphoblastic Leukemia (T-ALL). Acute Lymphoblastic Leukemia is the most common childhood cancer. Because T-ALL is a result of incorrect thymocyte development, research...
The purpose of this honors thesis research project is to investigate the molecular causes of childhood and infant T-cell acute lymphoblastic leukemias. T-cells are the work horses of the immune system, and like any organ, must develop properly to be fully functional. Improper development of thymocytes into T-cells can lead...
Atrial fibrillation is the most common cardiac arrhythmia, and the mechanisms that lead to this heart defect are not fully understood. Consequently, treatments for this defect do not currently reverse structural or molecular variations that lead to cardiac arrhythmia. Loss of the gene coding for the transcription factor Pitx2 leads...