The submarine Amsterdam-St. Paul (ASP) Plateau, bisected by the Southeast Indian Ridge (SEIR), is a bathymetric high rising ~2 km above the surrounding seafloor that includes the islands of Amsterdam and St. Paul; this excess volcanism is attributed to a mantle hot spot. We obtained new Sr, Nd, and Pb...
7,7'-Dihydroxy-8,8'-biquinolyl (azaBINOL) was prepared from 7-hydroxyquinoline via N,N-dimethyl O-quinol-7-yl carbamate by directed ortho-metallation followed by FeCl₃-mediated oxidative coupling of the 8-lithioquinoline intermediate. Saponification of the resulting dicarbamate provided crystalline (±)-azaBINOL in 56% overall yield. 6,6'-Bis(dimethylaminocarbonyl)-7,7'-dihydroxy-8,8´-biquinolyl was prepared from the same dicarbamate by a double anionic-Fries rearrangement in 43% yield. 7,7'-Bis(diethylamino-carbonyloxy)-6,6'-diiodo-8,8´-biquinolyl...
In this report, three studies are presented that aid in the development of drug discovery and their synthesis. In each, the importance of the marriage between computations and experiments is highlighted. Continued efforts in this vein are essential for future efforts towards improving human health.
The first case study investigated...
Members of the deltocephaline leafhopper genus Giprus Oman
live on grasses, primarily in the desert-scrub, chaparral, and
marine sand dune communities of western North America. Of 16
known species, 10 are undescribed. Recharacterization of the genus
results in exclusion of Laevicephalus incongruus Oman. Differentiation
of species is primarily dependent on...
Why are the fast Fourier transform and the fast
Hadamard transform fast? A transform can be computed by
multiplying a matrix times a vector, which normally requires 0(n²) operations. The matrices corresponding to
these transforms can be rearranged to eliminate redundant
computations resulting in O(nlogn) operations.
We investigate algebraic reasons...
Encryption is essential to the security of transactions and communications, but
the algorithms on which they rely might not be as secure as we all assume. In this
paper, we investigate the randomness of the discrete exponentiation function used
frequently in encryption. We show how we used exponential generating functions...
The general problem of classroom scheduling is well known to be NP-complete. A typical classroom scheduling problem is that of assigning students to a limited number of pieces of laboratory equipment. Frequently several identical pieces of equipment are available only at fixed hours and have limited access due to physical...