DNA is often described as the “blueprint for life”. In eukaryotes this information is contained within linear chromosomes of varying size and number. During cell division, the chromosomes must be faithfully segregated into each daughter cell to avoid disease and sustain life. This process is carried out by the kinetochore...
This research sought to identify the reasons physicians attributed for practicing in Oregon, the reasons for relocating out of Oregon, and the reasons for failures in recruiting physicians to Oregon. A random sample survey of 494 Oregon physicians identified the presence of economic and non-economic factors related to the recruitment...
PURPOSE Rural hospitals began to make significant changes in the 1990s by becoming integrated with larger health systems. The literature has correlated several key measures that determine the success of integrated health systems. These measures were quality, financial strength, community benefit, physician outcomes, and service changes. The purpose of this...
In response to genotoxic stress, ATR and ATM kinases phosphorylate H2A in fungi and H2AX in animals on a C-terminal serine.
The resulting modified histone, called γH2A, recruits chromatin-binding proteins that stabilize stalled replication forks or promote
DNA double-strand-break repair. To identify genomic loci that might be prone to replication...
Full Text:
. Lynch,a* Caitlin V. Mueller,a StevenFriedman,b Michael Freitag,b Zachary A. Lewisa
Department of
In response to genotoxic stress, ATR and ATM kinases phosphorylate H2A in fungi and H2AX in animals on a C-terminal serine.
The resulting modified histone, called γH2A, recruits chromatin-binding proteins that stabilize stalled replication forks or promote
DNA double-strand-break repair. To identify genomic loci that might be prone to replication...
In response to genotoxic stress, ATR and ATM kinases phosphorylate H2A in fungi and H2AX in animals on a C-terminal serine. The resulting modified histone, called γH2A, recruits chromatin-binding proteins that stabilize stalled replication forks or promote DNA double-strand-break repair. To identify genomic loci that might be prone to replication...
Shell-boring polychaetes pose economic risks for oyster aquaculture industries as they reduce the aesthetic quality of oyster products by creating unsightly mud-filled blisters on the inside of the shell. Recently there has been a reported uptick in infested oysters on commercial farms along the west coast of the US, which...
Transgenic biotechnology holds enormous potential as a tool to address global food insecurity. Transgenic food crops have been shown to increase food availability and food system security by incorporating disease, pesticide and drought resistance. Production costs of transgenic crops are lower due to the reduced need for costly pesticides and...
Ascorbic acid, or vitamin C, is well known as a co-factor for proline-hydroxylase and as an anti-oxidant. However, it is also capable of forming covalent bonds, particularly in the role of a nucleophile, henceforth termed 'ascorbylation'.
The ascorbylation of electrophiles can occur under physiological conditions. Furthermore, there are a number...
Histones, as part of nucleosomes, are responsible for DNA packaging in chromosomes. They also affect DNA expression by a multitude of post-translational modifications, especially prevalent on the amino terminus of histones. Co-activator protein complexes “write”, “read”, or “erase” histone modifications, and in balance determine which sections of DNA are free...