The anticonvulsant drug carbamazepine (CBZ) is a commonly prescribed drug that is used to treat patients with neurological disorders including epilepsy and bi-polar disorder. CBZ has a narrow range of efficacy: Below the therapeutic dose, seizures and other conditions are not controlled, and above the recommended window, patients experience side...
Personal health monitoring tools, a subset of point-of care-diagnostics, enable more frequent testing of chronic health conditions outside of a clinic setting and can inform personalized therapy or support telehealth diagnostic capabilities. While there is evidence that regular monitoring of chronic conditions can lead to better health outcomes and lower...
Paper-based microfluidic assays, like the common pregnancy test, allow for rapid screening at the point- of-care at low cost and with no instrumentation. Fabric has many similar properties to paper, but is more flexible and durable, making it a promising option for use in a variety of diagnostic and screening...
Remote health monitoring tools have significant potential to revolutionize the current healthcare paradigm. Such tools could improve efficiencies in healthcare by alerting patients and doctors to abnormal health conditions in real time, shortening the time to diagnose and treat ailments. To meet these needs, we pursue the development of fabric-based...
Arsenic in its inorganic form is naturally present in groundwater. Continued exposure to arsenic contaminated water can result in long lasting health complications, ranging from cognitive development issues to cancer. One method which may be convertible to a field test is the use of PEG functionalized gold nanoparticles which aggregate...
Paper-based assays for HIV diagnosis are cheap, portable, and require little to no skilled training, electricity, or expensive equipment to perform successfully. However, there is a need for tests with lower limits of detection (LOD) for diagnosing infection at the earliest stages. Effective labeling to increase signal-to-noise ratio is critical...
Paper microfluidic devices are capable of processing fluids using capillary flow in materials that are lower cost than the standard materials used in microfluidics. Due to the low cost of their fabrication and minimal requirements for instrumentation, paper microfluidic devices are ideal for use in low-resource settings. They have the...
Monitoring phenylalanine (Phe) levels in the blood of individuals with phenylketonuria (PKU) is a critical component of therapy. Existing tests for PKU require high-resource laboratories, which are not available to many populations and cannot provide the real-time feedback required for effective therapy monitoring. It would be ideal to develop an...
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Dr. ElainFu
Abstract
Monitoring phenylalanine (Phe) levels in the blood of individuals
Currently, wax printing is limited to materials that can be processed by a wax printer. Wax transfer printing is a method that allows previously unusable materials to be patterned with wax via an intermediate template. Millipore cellulose, a material too thick to be processed by a wax printer, was patterned...
Phenylketonuria (PKU) is a genetic inborn metabolic disorder which inhibits the functional production of the enzyme phenylalanine hydroxylase (PAH). It currently affects one in 15,000 Americans and is the most common amino acid metabolism error found in newborns. Individuals affected with PKU are incapable of metabolizing the amino acid, phenylalanine...