Measurements on growth traits up to 41 years of age
from 68 progeny sites in eight first-generation breeding
zones of coastal Douglas-fir (Pseudotsuga menziesii
[MIRB.] FRANCO var. menziesii) in the US Pacific Northwest
were used to investigate age trends of genetic parameters
and to determine optimum age of selection. Heritabilities...
T cells are one of the key cells in the immune system. Although they are
not the first line of defense against a pathogen, their functions can greatly enhance
the phagocytosis and destruction of pathogens as well as the development of
antibody responses. Furthermore, even when responding T cells have...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized
for their immunosuppressive activity, which is mediated through an
intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR).
Laboratory animals exposed to TCDD are less resistant to infection and have severely
impaired humoral and cell-mediated immune responses. This dissertation addressed
the hypothesis that...
The immune system has been identified as a very sensitive target for the toxic effects of 2,3,7,S-tetrachlorodibenzo-p-dioxin (TCDD). Exposure to TCDD has been shown to disrupt the generation of both cell-mediated and humoral T cell-dependent immunity in laboratory animals; however, the mechanism remains unknown. In this dissertation, the hypothesis is...
In the problem of testing the median using a random sample from a
certain distribution, and if no other parametric family is suggested,
the t-test is known to be the optimal procedure when this distribution
is normal. If the sample appears to be non-normal, one has the choice
Eukaryotic ribosome biogenesis involves ~200 assembly
factors, but how these contribute to ribosome
maturation is poorly understood. Here, we
identify a network of factors on the nascent 60S subunit
that actively remodels preribosome structure. At its hub is
Rsa4, a direct substrate of the force-generating ATPase
Rea1. We show that...
to export these to the Ponderosa Client for
The Antarctic contribution to sea level is a balance between ice loss along the margin and accumulation in the interior. Accumulation records for the past few decades are noisy and show inconsistent relationships with temperature. We investigate the relationship between accumulation and temperature for the past 31 ka using high-resolution records...
• Supporting Information S1
T. J. Fudge,
Fudge, T. J., B. R