The human cathelicidin antimicrobial peptide (CAMP) is a broad spectrum microbicidal agent and modulator of both the innate and adaptive immune system. It is induced by 1,25-dihydroxyvitamin D (1,25(OH)₂D₃) through activation of the vitamin D receptor (VDR) and primary bile salts through activation of the xenobiotic nuclear receptor farnesoid X...
An interlaboratory study of Mg/Ca and Sr/Ca ratios in three commercially available carbonate reference
materials (BAM RS3, CMSI 1767, and ECRM 752-1) was performed with the participation of
25 laboratories that determine foraminiferal Mg/Ca ratios worldwide. These reference materials containing
Mg/Ca in the range of foraminiferal calcite (0.8 mmol/mol to...
Cutaneous melanoma remains the deadliest form of skin cancer arising from malignant transformation of pigment-producing melanocytes, with a diagnosis of metastasis indicating a median survival rate of less than a year. Solar ultraviolet (UV) radiation, especially childhood sun exposure, is an important etiological risk factor of melanoma. This DNA damage...
The enantioselective total synthesis of quinolizidine-containing natural product cermizine D and formal syntheses of senepodine G and cermizine C has been achieved. These natural products are members of the lycopodium alkaloids, which have attracted significant attention due to their exciting biological activities and the diverse structural scaffolds. Key steps in...
A major tipping point of Earth's history occurred during the mid-Pliocene: the onset of major Northern-Hemisphere Glaciation (NHG) and of pronounced, Quaternary-style cycles of glacial-to-interglacial climates, that contrast with more uniform climates over most of the preceding Cenozoic and continue until today (Zachos et al., 2001). The severe deterioration of...
Humans move frequently and tend to carry parasites among areas with endemic malaria and into areas where local transmission is unsustainable. Human-mediated parasite mobility can thus sustain parasite populations in areas where they would otherwise be absent. Data describing human mobility and malaria epidemiology can help classify landscapes into parasite...
Douglas-fir provides social, economic, and ecological benefits in the Pacific Northwest (PNW). In addition to timber, forests support abundant plant and animal biodiversity and provide socioeconomic viability for many rural communities. Products derived from Douglas-fir account for approximately 17% of the U.S. lumber output with an estimated value of $1.9...
Estimates of the relative motion between the Hawaiian and Louisville hot spots have consequences
for understanding the role and character of deep Pacific-mantle return flow. The relative motion between
these primary hot spots can be inferred by comparing the age records for their seamount trails. We report
⁴⁰Ar/³⁹Ar ages for...
Full Text:
. Koppers, J. R. Wijbrans, K.
M. Haase, P. Stoffers, W. Jokat, and D. Garbe-Schönberg (2013), Constraints
Silicic caldera-forming eruptions are some of the largest and most destructive volcanic eruptions known, and present significant local and global hazards. The underlying processes within crustal magma plumbing systems that lead to the accumulation and eruption of large volumes of evolved magma remain enigmatic, yet there is broad consensus that...
It is well documented that greater sage-grouse (Centrocercus urophasianus; hereafter sage-grouse) populations have been in decline throughout their range in the western United States. Currently, sage-grouse occupy approximately 56% of their historic distribution prior to European settlement. Numerous factors have been cited as potential causes for declining productivity and contraction...