Le futur du secteur de la pèche en Andalousie doit être analyse dans le contexte d'une stratégie de développement régional liée a une économie de plus en plus mondialisée. L'union européenne, d'où l’Andalousie fait partie, veut-elle être productrice de poisson, ou bien, exclusivement une commerçante des produits pécheurs? la question...
Le future du secteur de la pêche en Andalousie doit être analysé dans le contexte d'une stratégie de développement régional liée a une économie de plus en plus mondialisée.
l'union européenne, d'où l'Andalousie en fait partie, veut-elle être productrice de poisson, ou bien, exclusivement une commerçante des produits pêcheurs? la...
Natural products (secondary metabolites) are small organic molecules derived
from plants, microbes, and marine organisms that have served as a diverse source of
useful compounds pharmaceuticals. New biologically active natural products are critical
as anti-infective and cancer drug leads. Cyanobacteria, or blue-green algae, produce
diverse cytotoxic metabolites that represent potential...
This thesis describes the chemical investigation of marine cyanobacteria collected in Madagascar and Panama with an emphasis on the isolation and structure elucidation of medicinally relevant secondary metabolites.
A collection of the marine cyanobacterium Lyngbya majuscula from the Radames Islands, Madagascar yielded two new cyclic depsipeptides, radamamides A and B,...
Enzymatic hydrolysis is a critical process in the conversion of lignocellulosic biomass into biofuels and biochemicals. Achieving high efficiencies and productivity during the enzymatic hydrolysis of biomass is the key for the commercially viable process. Downstream processing challenges require high product titers which in turn require the use of high...
Marine organisms produce a variety of secondary metabolites for defense, communication, and reproduction. While these uses are essential for the organisms' survival, marine natural products have demonstrated their value to human society as well. Asian countries used algae for centuries to treat or prevent illnesses as wide-ranging as cough, gout,...
Coibamide A is a methyl-stabilized cyclic depsipeptide with a lariat side chain that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups program based in Panama. Previous testing of this potent and selective growth-inhibitory agent in the National Cancer Institute (NCI) in vitro 60 human...
This thesis is an account of investigation on the natural products deriving from various marine algae and has resulted in the discovery of eleven novel bioactive metabolites. Isolation and characterization of these new molecules were carried out using different chromatographic techniques and by analyses of different spectroscopic data, respectively. Using...
This thesis details investigations of marine cyanobacterial secondary metabolism, with emphasis on a strain of Phormidium sp. collected in Indonesia. These studies assessed the effects of nineteen putative elicitor compounds on the growth and metabolite production of five species of marine cyanobacteria, biosynthetic investigation of an intriguing secondary metabolite, phormidolide,...
Studies toward the total syntheses of highly potent cytotoxic alkaloids
including the bromopyrrole alkaloids and indole alkaloids were conducted and are
described. Studies carried out in the course of this dissertation consist of five total syntheses of natural products that include bromopyrrole alkaloids nagelamide A, D and agelastatin D as...