In rodent models as well as in fish models there are significant
species differences in the susceptibility toward aflatoxin B₁ (AFB₁)
carcinogenesis. Mouse is less susceptible toward AFB₁ carcinogenesis
than rat. Researchers have come to the conclusion that the lower
susceptibility of mice is not a result of less effective...
Lipid peroxidation is believed to be an important
process in the development of cellular injury. In
addition to the degradation of biological membranes,
increasing evidence indicates that lipid peroxidation can
alter the structure and function of DMA.
The present study examines the peroxidation of
nuclear membranes and the capacity of...
Sulfite mutants representing five complementation groups, previously derived from
an ethyl methanesulfonate-treated haploid strain of Saccharomyces cerevisiae were studied.
Although the wildtype S. cerevisiae strain used (isogenic to X2180-1 A) had a basal
tolerance for sulfite (7 μM free H₂SO₃), the sensitive and resistant mutants were found to
A rapid and sensitive HPLC method for quantifying both the
reduced and oxidized forms of glutathione simultaneously in woody
plant tissues was developed. This method was applicable to a variety
of woody plant species and different tissues. Total glutathione
content in the bark tissue of seven of the woody plant...
Nuclear Factor, Erythroid Derived 2, Like 2 (NFE2L2 or Nrf2) is the primary transcription factor in cellular defense against oxidative and xenobiotic stresses in higher eukaryotes. This basic leucine zipper transcription factor regulates over 200 antioxidant, detoxification, and lipid metabolizing genes by binding to the Antioxidant Response Element (ARE; a...
Hallmarks of aging include the accumulation of aberrant proteins and a lower resistance to stresses. Because the endoplasmic reticulum (ER) functions to fold proteins and possesses unique stress sensing pathways, the central hypothesis of this dissertation is that the ER is a target of cellular aging and significantly underlies these...
Glutathione (GSH) is the predominant low molecular weight thiol antioxidant
in liver tissue. GSH plays an important role in maintaining the intracellular thiol redox
ratio as well as detoxification of electrophiles and xenobiotics. Aging leads to a significant decline (35%; P ≤ 0.05) in hepatocellular GSH levels. Using young (2-4...