Many substances in the plant kingdom and in man's diet occur
as glycosides. Recent studies have indicated that many glycosides
that are not mutagenic in tests such as the Salmonella/microsome
test become mutagenic upon hydrolysis of the glycosidic linkages.
The Salmonella/microsome test utilizes a liver homogenate to approximate
mammalian metabolism...
Hop aroma in beer is related to the unique compositional chemistry of the hops used in the brewing process. While the range of these compositions is quite diverse and primarily dependent on hop cultivar¹, other studies have also shown that cultivation, seasonality, harvesting², processing³⁴, and storage practices⁵⁶ contribute to differences...
In an effort to isolate and characterize cardiac glycosides C-17
binding site(s), we have synthesized different affinity and photoaffinity
C-17 side chain probes. These probes were screened for their
ability to inhibit Na⁺,K⁺-ATPase enzyme, a pharmacological receptor
of cardiac glycosides. The enzyme was isolated from hog kidney.
Screening of these...