Index Catalog // ScholarsArchive@OSU

Analysis of Mercury Content in Dried Urine of Individuals with Amalgam Fillings Through theUtilization of Direct Mercury Analysis

Creator:: Kapur, Suchit
Abstract:: Mercury exposure is widely common throughout the world, ranging from sources such as dental amalgams, fish and seafood consumption, industrial mining, and medicine. A straightforward, efficient, and affordable protocol to measure urine mercury content would greatly contribute to assessing one’s mercury exposure and in categorizing populations that are more vulnerable...
Resource Type:: Honors College Thesis
Full Text:: : ______________________________________________________ Dr. Adrian Gombart Mercury exposure is widely common throughout the world, ranging from sources

Antimicrobial peptide regulation by small molecules in humans and other primates

Creator:: Sinnott, Brian D.
Abstract:: Antimicrobial peptides (AMPs) play an important role in the innate immune system. Determining the pathways by which these proteins are regulated allows for modulation of their expression for better health. Two families of antimicrobial peptides have been studied in humans: cathelicidins and defensins. There is a single cathelicidin in humans...
Resource Type:: Masters Thesis
Full Text:: other Primates Abstract approved: Adrian F. Gombart Antimicrobial peptides (AMPs) play

Changes in gene expression related to the decline of the aging immune system

Creator:: Tran, Jenny K. and Gombart, Adrian F.
Abstract:: In this study, the gene expression levels between 6 month old mice and 26 month old mice were compared. The purpose of this research was to identify genes that are differentially regulated due to aging. The results showed 148 significantly differentiated genes in the analysis of a total of 44,170...
Resource Type:: Research Paper and Presentation

The Cathelicidin Anti-microbial peptide gene alters the mouse gut microbiome

Creator:: Rouches, Miles V.
Abstract:: The gut microbiome influences human disease including Type 2 diabetes, obesity and metabolic syndrome and interacts with the innate immune system. The human cathelicidin antimicrobial peptide (hCAMP), an important component of the innate immune system, and vitamin D and xanthohumol, a natural compound found in beer hops, regulate its expression....
Resource Type:: Honors College Thesis
Full Text:: (5R01AT009168) to Adrian F. Gombart. I would like to thank the members of the Gombart lab for their daily

Transcriptional regulation of the human cathelicidin antimicrobial peptide gene

Creator:: Guo, Chunxiao
Abstract:: Human cathelicidin antimicrobial peptide (CAMP/LL-37) is a cationic antimicrobial peptide that is widely expressed by myeloid and epithelial cells at the human-environment interface. It possesses broad spectrum antimicrobial capacity against bacteria, fungi and viruses. In addition to its direct antimicrobial activity, CAMP/LL-37 also attracts and recruits monocytes, neutrophils and other...
Resource Type:: Dissertation
Full Text:: Cathelicidin Antimicrobial Peptide Gene. Abstract approved: Adrian F. Gombart Human cathelicidin

The effect of dietary compounds on human cathelicidin antimicrobial peptide gene expression mediated through farnesoid X receptor and its potential role in gastrointestinal health

Creator:: Campbell, Yan
Abstract:: The human cathelicidin antimicrobial peptide (CAMP) is a broad spectrum microbicidal agent and modulator of both the innate and adaptive immune system. It is induced by 1,25-dihydroxyvitamin D (1,25(OH)₂D₃) through activation of the vitamin D receptor (VDR) and primary bile salts through activation of the xenobiotic nuclear receptor farnesoid X...
Resource Type:: Dissertation
Full Text:: approved: Adrian F. Gombart The human cathelicidin antimicrobial peptide (CAMP) is a broad spectrum

A Promising Approach for Preventing of Diet-Induced Obesity and Fatty Liver Using Tetrahydroxanthohumol, A Synthetic Derivative of Xanthohumol

Creator:: Zhang, Yang
Abstract:: Obesity and metabolic syndrome (MetS) affect over 1.9 billion adults and 12.7 million youth in the US. If all of today’s obese American youth become obese adults, the total societal costs over their lifetime may exceed $1.1 trillion. We show that feeding rodents a high-fat diet supplemented with xanthohumol (XN)...
Resource Type:: Dissertation
Full Text:: : _____________________________________________________________________ Adrian F. Gombart Obesity and metabolic syndrome (MetS) affect over 1.9 billion adults and

Towards a Better Understanding of How the Dietary Supplement Xanthohumol Can Improve Health

Creator:: Logan, Isabelle E.
Abstract:: Xanthohumol, a prenylated flavonoid found in hops and beer, possesses a long-standing reputation to improve health. Xanthohumol’s cytotoxicity to a wide variety of cancer cell lines is well-established. Herein we provide further insight into the cytotoxicity of not only xanthohumol, but also its non-estrogenic derivatives, to a number of colonic...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________ Adrian F. Gombart Xanthohumol, a prenylated flavonoid found in hops and beer, possesses a

OpMNPV p32, a baculovirus polyhedral envelope-associated protein : genetic location, nucleotide sequence, transcriptional mapping and immunocytochemical characterization

Creator:: Gombart, Adrian F.
Abstract:: Baculoviruses comprise a diverse group of pathogens infectious for members of the insect orders Lepidoptera, Hymenoptera and Diptera. Of the three subgroups, two (subgroup A, nuclear polyhedrosis virus (NPV) and subgroup B, granulosis virus (GV) are occluded in a crystalline protein structure while the remaining subgroup (subgroup C, non-occluded virus)...
Resource Type:: Masters Thesis
Full Text:: characterization AN ABSTRACT OF THE THESIS OF Adrian F. Gombart for the degree of Master of Science in Genetics

Impact of Vitamin E Deficiency on Hepatic Gene Expression of CRAL_TRIO Family Proteins in a Premier Vertebrate Animal Model

Creator:: Watt, Alexander T.
Abstract:: Vitamin E (vitE) is a group of lipid-soluble antioxidants- of which alpha-tocopherol is the most biologically active and only form considered to be an essential nutrient. Through preferential binding and trafficking, the alpha-tocopherol transfer protein (α-TTP) regulates the concentration of vitE in the body. The impact of vitE deficiency on...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Adrian Gombart, Committee Member, representing Department of Biochemistry and Biophysics

ScholarsArchive@OSU

Analysis of Mercury Content in Dried Urine of Individuals with Amalgam Fillings Through theUtilization of Direct Mercury Analysis

Antimicrobial peptide regulation by small molecules in humans and other primates

Changes in gene expression related to the decline of the aging immune system

The Cathelicidin Anti-microbial peptide gene alters the mouse gut microbiome

Transcriptional regulation of the human cathelicidin antimicrobial peptide gene

The effect of dietary compounds on human cathelicidin antimicrobial peptide gene expression mediated through farnesoid X receptor and its potential role in gastrointestinal health

A Promising Approach for Preventing of Diet-Induced Obesity and Fatty Liver Using Tetrahydroxanthohumol, A Synthetic Derivative of Xanthohumol

Towards a Better Understanding of How the Dietary Supplement Xanthohumol Can Improve Health

OpMNPV p32, a baculovirus polyhedral envelope-associated protein : genetic location, nucleotide sequence, transcriptional mapping and immunocytochemical characterization

Impact of Vitamin E Deficiency on Hepatic Gene Expression of CRAL_TRIO Family Proteins in a Premier Vertebrate Animal Model

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