Here we report a new transgenic expression system by combination of liver-specific expression,
mifepristone induction and Cre-loxP recombination to conditionally control the expression of oncogenic
kras[superscript]V12. This transgenic system allowed expression of kras[superscript]V12 specifically in the liver by a brief exposure
of mifepristone to induce permanent genomic recombination mediated by...
Full Text:
, ZhiyuanGong
1
*
1
Department of Biological Sciences, National University of Singapore, Singapore
Here we report a new transgenic expression system by combination of liver-specific expression,
mifepristone induction and Cre-loxP recombination to conditionally control the expression of oncogenic
kras[superscript]V12. This transgenic system allowed expression of kras[superscript]V12 specifically in the liver by a brief exposure
of mifepristone to induce permanent genomic recombination mediated by...
Full Text:
., & Gong, Z. (2016). Development of a
conditional liver tumor model by mifepristone-inducible Cre
Hepatocellular carcinoma (HCC) is currently one of the top lethal cancers with an increasing
trend. Deregulation of MYC in HCC is frequently detected and always correlated with poor
prognosis. As the zebrafish genome contains two differentially expressed zebrafish myc
orthologs, myca and mycb, it remains unclear about the oncogenicity of...
Hepatocellular carcinoma (HCC) is currently one of the top lethal cancers with an increasing
trend. Deregulation of MYC in HCC is frequently detected and always correlated with poor
prognosis. As the zebrafish genome contains two differentially expressed zebrafish myc
orthologs, myca and mycb, it remains unclear about the oncogenicity of...
Full Text:
, decision to publish, or preparation of
the manuscript.
Competing Interests: ZhiyuanGong is currently an
Here we report a new transgenic expression system by combination of liver-specific expression, mifepristone induction and Cre-loxP recombination to conditionally control the expression of oncogenic kras[superscript]V12. This transgenic system allowed expression of kras[superscript]V12 specifically in the liver by a brief exposure of mifepristone to induce permanent genomic recombination mediated by...
Hepatocellular carcinoma (HCC) is currently one of the top lethal cancers with an increasing trend. Deregulation of MYC in HCC is frequently detected and always correlated with poor prognosis. As the zebrafish genome contains two differentially expressed zebrafish myc orthologs, myca and mycb, it remains unclear about the oncogenicity of...
RAS and Rho small GTPases are key molecular switches that control cell dynamics, cell
growth and tissue development through their distinct signaling pathways. While much has been
learnt about their individual functions in both cell and animal models, the physiological and
pathophysiological consequences of their signaling crosstalk in multi-cellular context...
RAS and Rho small GTPases are key molecular switches that control cell dynamics, cell
growth and tissue development through their distinct signaling pathways. While much has been
learnt about their individual functions in both cell and animal models, the physiological and
pathophysiological consequences of their signaling crosstalk in multi-cellular context...
RAS and Rho small GTPases are key molecular switches that control cell dynamics, cell
growth and tissue development through their distinct signaling pathways. While much has been
learnt about their individual functions in both cell and animal models, the physiological and
pathophysiological consequences of their signaling crosstalk in multi-cellular context...
RAS and Rho small GTPases are key molecular switches that control cell dynamics, cell
growth and tissue development through their distinct signaling pathways. While much has been
learnt about their individual functions in both cell and animal models, the physiological and
pathophysiological consequences of their signaling crosstalk in multi-cellular context...
