The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we
show that treatment of mice with glycine-b-muricholic acid (Gly-MCA) inhibits FXR signalling
exclusively in intestine, and improves metabolic parameters in mouse models of obesity.
Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we
show that treatment of mice with glycine-b-muricholic acid (Gly-MCA) inhibits FXR signalling
exclusively in intestine, and improves metabolic parameters in mouse models of obesity.
Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
Full Text:
obesity-related metabolic dysfunction
Jiang, C., Xie, C., Lv, Y., Li, J., Krausz, K. W., & Gonzalez, F. J
The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-b-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
Both Ways is a collection of essays, prose, poetry, and "proems" which attempts to investigate the phenomena of multirace and multisexuality issues in greater detail. These works particularly explore questions of liminality and marginalization within American culture as it relates to characters who are experiencing anomie and alienation because of...
Assessing the impact of fungal decay in wood structures poses a major challenge for building inspectors. Although models have been developed to predict degradation rate of building components in varying climatic conditions, most are hampered by the lack of fundamental data on effects of fungal attack on engineering properties. Developing...
Objective: To examine the relationship between wealth and cardiovascular disease risk factors among Hispanic/Latinos of diverse backgrounds.
Design: This cross-sectional study used data from 4971 Hispanic/Latinos, 18-74 years, who participated in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) baseline exam and the HCHS/SOL Sociocultural Ancillary Study. Three objectively measured...
The present study was undertaken to determine, by measurement
of nuclear DNA, the degrees and frequencies of ploidy in the
last larval instar of the moth Galleria mellonella Linnaeus. While
such data have been amassed for a wide variety of vertebrate tissues,
few studies have been concerned with invertebrates and...
The spermiogenesis of Mytilus edulis (a marine mussel) has
been studied, employing techniques of light and electron microscopy
and cytochemical preparations. The observations trace the development
of the acrosomal complex, the nucleus, the mitochondrial
middle-piece, and the flagellum.
In early spermatids numerous membrane-bounded proacrosomal
vesicles arise from several Golgi complexes...