Fungi have long been used for discovery of new chemical scaffolds. In the clinical setting, the fungal natural products penicillin, statins, and cyclosporine have revolutionized medicine to treat diseases and infections. In the environment, fungal natural products have been used as herbicides, fungicides, and insecticides to protect crops, livestock, and...
Current natural product (NP) research is limited by its reliance on bioassay-guided fractionation to identify bioactive compounds in mixtures. Computational approaches may improve NP research by correlating mass spectra (MS) and nuclear magnetic resonance spectra (NMR) of bioactive mixtures to their bioactivity patterns. In this study, I use artificial neural...
In this dissertation, a novel method for analyzing computed transition states (TS) for organic reactions is disclosed. It introduces the use of localization-delocalization matrices as parameters in a linear free energy relationship to determine the transition state interactions responsible for differences in energy between the major and minor TS in...
Exploring bioactive natural products has contributed largely to clinically approved drugs we have been using over the last 100 years. Especially among the anti-infective drugs, around 70% of currently used antibiotics were discovered or derived from microbial secondary metabolites, among them compounds like vancomycin, chloramphenicol, and erythromycin. Facing the unavoidable...
Cell-to-cell communication by chemical signals, termed quorum sensing (QS), is a common regulatory scheme in the microbial world. Pseudomonas aeruginosa¸ an opportunistic pathogen of burn wounds and cystic fibrosis lungs, uses QS to control the expression of hundreds of genes, particularly those necessary for population level benefits such as biofilm...
Previous investigations have failed to show benefits of low level laser therapy (LLLT) for tendon healing in horses, contrary to reports in other species. We hypothesized that delivery of LLLT at manufacturer-recommended energy fluence through equine cadaver skin to equine tendon-derived fibroblasts in vitro would increase cell proliferation, metabolic activity...
This thesis is an IRB-exempt oral history focused on the non-profit Corvallis Multicultural Literacy Center (CMLC) in Corvallis, Oregon. The CMLC, formerly on 9th Street, was known to many community members as the Yellow House. The Yellow House was a dedicated community-based space where people of all cultures could come...
The Mixteco primarily reside in the Mexican State of Oaxaca in Southwestern Mexico. They have been arriving in larger numbers then ever before to this part of the North American continent in the last twenty years.Their experience is composed of different dynamics compared to those of their mainstream Mexican counterpart....
The Mixteco primarily reside in the Mexican State of Oaxaca in Southwestern Mexico. They have been arriving in larger numbers then ever before to this part of the North American continent in the last twenty years.Their experience is composed of different dynamics compared to those of their mainstream Mexican counterpart....
The Second Pandemic had a profound impact on the people of Europe. In the few years between 1347 and 1350, a new epidemic disease spread across the entirety of Europe and killed between one third and two thirds of the population. While this initial wave was important, the real significance...