DNA from the human squamous carcinoma cell line, SK-MES-1, and the
plasmids, pUC EJ6.6 containing H-ras oncogene, pSVc-mycl containing
cellular myc gene, pNRSac containing N-ras oncogene, pBR SV containing
SV40 virus DNA, pSV2-neu containing neu oncogene and pSV2-neo
containing neomycin resistant gene were used to transform Balb serum-free
derived mouse...
Serum-free mouse embryo (SFME) cells are derived
in medium in which serum is replaced with growth
factors and other supplements. They display unusual
properties. They do not lose proliferative potential
or show gross chromosomal aberration upon extended
culture, they depend on epidermal growth factor (EGF)
for survival, and are reversibly...
These studies were conducted to examine the
influence of several variables on the growth hormone binding
protein (GHBP) in serum of pigs. Continuous long term
porcine somatotropin (pST) injections (daily for 6-7 wk)
increased GHBP activity (p < .05). However, periodic short
term pST injections (daily, every second d or...
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Met is a prognostic indicator of colorectal cancer patient survival. Therapies that target Met may therefore have beneficial outcomes in the clinic. Recently, EGCG was reported to suppress Met activation, although the mechanisms were not elucidated. HCT116 and HT29 human colon cancer cells were used to examine the relationships between...
As a major natural component of the extracellular matrix (ECM),
hyaluronic acid (HA) is an excellent choice for biomimetic, biocompatible
therapeutic materials. Furthermore, thiol-modified forms of HA are capable of
forming macroporous hydrogels that allow for both controlled cytokine release and
extensive vessel in-growth. It has previously been shown that...
Biocompatible hydrogels composed of covalently crosslinked, chemically modified hyaluronan (HA), gelatin (Gtn), and heparin (Hp) were synthesized for controlled release of human vascular endothelial growth factor (VEGF) or basic fibroblast growth factor (bFGF). We hypothesized that inclusion of small quantities of heparin in these gels would result in regulated growth...
Serum-free mouse embryo (SFME) cells, which were derived
from 16-day-old Balb/c mouse embryo brain, grow in absence of
serum without losing genomic normality or proliferative
potential, and require epidermal growth factor (EGF) for
normal growth. EGF is a well studied mitogen that binds to a
specific receptor on the cell...