Index Catalog // ScholarsArchive@OSU

Exploring Potential Therapeutics Using a Drug Screening Platform in Drosophila melanogaster

Creator:: D'Haem, Maddie
Abstract:: Mechanisms of aging and age-related diseases are not completely understood in humans. Studying model organisms like Drosophila melanogaster, also known as the common fruit fly, can help humans better understand the aging process and diseases related to aging. From previous studies demonstrated in Drosophila, an accelerated aging model has been...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Tory Hagen, Committee Member, representing Biochemistry & Biophysics

Ibuprofen Treatment Causes NMDA and AMPA Receptor Hyperactivity in Female Wild Type and Heterozygous 5xFAD mice but not Males

Creator:: Rauenhorst, Jacob
Abstract:: With Alzheimer’s disease being the most prominent form of dementia, finding potential treatments for the disease is imperative. This study explored the non-steroidal anti-inflammatory drug ibuprofen as a potential treatment to normalize the hyperactive N-methyl-d-aspartate receptor (NMDAR) within the 5xFAD mice early in the disease pathology before cognitive decline. Female...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Tory Hagen, Committee Member, representing Department Biochemistry and Biophysics

Age-related response of isolated rat hepatocytes to menadione and (R)-[alpha]-lipoic acid

Creator:: Graves, Jason T.
Abstract:: Age-related decline in the capacity of endogenous antioxidant systems complicates pharmaceutical use by the elderly by potentially increasing the toxicity of some compounds. Of particular interest is chemical detoxification via glutathione (GSH) and attendant GSH-requiring detoxification enzymes, e.g. GSH peroxidases (GPX) and GSH S-transferase (GST). These enzymes have been shown...
Resource Type:: Undergraduate Thesis

Cellular mechanisms of muscle weakness and fatigability in individuals with multiple sclerosis

Creator:: Garner, Dena J. P.
Abstract:: Muscle weakness and fatigue are debilitating symptoms of multiple sclerosis (MS). Approximately 50% of muscle weakness and fatigue have been attributed to deficits within the peripheral nervous system, specifically mechanisms residing in the muscle. The goals of this study were to identify the cellular mechanisms of contraction within the muscle...
Resource Type:: Dissertation
Full Text:: members, Steve Hannigan- Downs, Tory Hagen, and Rebecca Johnson, who took the time to read and

Biomechanical Demands and Postural Control During Exercises Commonly Performed by Older Adults in Falls Prevention Programs

Creator:: Stutzenberger, Lyndsay R.
Abstract:: Exercise programs that are individualized and moderately challenge balance to address falls risk factors are recommended for preventing falls in community-dwelling older adults. Little is known regarding the biomechanical and postural control demands in exercises commonly performed in falls prevention programs. Twenty-two non-sedentary, healthy older adults (11 men, 11 women,...
Resource Type:: Dissertation
Full Text:: analysis, and review and revision of the manuscripts. Dr. Tory Hagen assisted with the design of the

Oxidative stress in amyotrophic lateral sclerosis : the role of cellular senescence and glutathione

Creator:: Beilby, Pamela R.
Abstract:: Amyotrophic lateral sclerosis (ALS) is a devastating neurological disorder characterized by neuromuscular junction decay, motor neuron death, progressive paralysis, and eventually death of the individual, usually by respiratory failure. Oxidative stress is a prominent hallmark of the disease and is often accompanied and exacerbated by mitochondrial dysfunction and neuroinflammation. This...
Resource Type:: Dissertation
Full Text:: , Kathy Magnusson, Barb Taylor, and Tory Hagen, who have provided guidance and encouragement

The effects of enhanced expression of the GluN2B (NR2B) subunit of the N-methyl-D-aspartate (NMDA) receptor on memory in aged animals

Creator:: Brim, Brenna L.
Abstract:: As the aging population continues to grow worldwide, age-related complications are becoming more apparent within the aging population. One of the first age-related complications to become apparent is age-associated memory impairment and it can make the elderly more dependent on caregivers early on. The N-methyl-D-aspartate (NMDA) receptor is important to...
Resource Type:: Dissertation

Modulation of deoxyribonucleoside triphosphate levels, DNA synthesis rates and fidelity in mammalian cells

Creator:: Martomo, Stella A.
Abstract:: Deoxyribonucleoside triphosphate (dNTP) concentrations measured in cells are not symmetric. dGTP almost always represents only 5-10% of the total dNTP pools in cells. In an in vitro replication system involving semiconservative replication from an SV 40 origin, the mutation frequency of an M13 phagemid replicated by human cell extracts in...
Resource Type:: Dissertation
Full Text:: , Dr. Tory Hagen and Dr. Soichi Kimura; also Dr. Isaac Wong. Dr. Jeff Greenwood, Dr. Sam Bradford

Influence of aging and behavioral experience on expression of GluN1 splice variants of the NMDA receptor in prefrontal cortex of mice brain

Creator:: Das, Siba Ranjan
Abstract:: As the aging population continues to grow the world over, age related complications become more and more apparent among the elderly population. One such complication is age associated memory impairment, which makes the elderly more dependent on caregivers early on. NMDA receptors in the brain are important for memory formation,...
Resource Type:: Dissertation
Full Text:: as a researcher. I would like to thank my graduate committee members Dr. Joseph Beckman, Dr. Tory

Identification and quantitation of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites in vivo as biomarkers of oxidative stress

Creator:: Kuiper, Heather C.
Abstract:: Oxidative stress occurs when the balance between reactive oxygen species and antioxidant defense mechanisms in the body becomes tipped heavily in favor of the reactive oxygen species. Reactive oxygen species can be present in excess due to elevated O2 levels, radiation, infection, smoking, or even excessive exercise. It is also...
Resource Type:: Dissertation
Full Text:: committee, Dr. Taifo Mahmud, Dr. Rosita Proteau, Dr. Tory Hagen, and Dr. Michael Borman for their guidance

ScholarsArchive@OSU

Exploring Potential Therapeutics Using a Drug Screening Platform in Drosophila melanogaster

Ibuprofen Treatment Causes NMDA and AMPA Receptor Hyperactivity in Female Wild Type and Heterozygous 5xFAD mice but not Males

Age-related response of isolated rat hepatocytes to menadione and (R)-[alpha]-lipoic acid

Cellular mechanisms of muscle weakness and fatigability in individuals with multiple sclerosis

Biomechanical Demands and Postural Control During Exercises Commonly Performed by Older Adults in Falls Prevention Programs

Oxidative stress in amyotrophic lateral sclerosis : the role of cellular senescence and glutathione

The effects of enhanced expression of the GluN2B (NR2B) subunit of the N-methyl-D-aspartate (NMDA) receptor on memory in aged animals

Modulation of deoxyribonucleoside triphosphate levels, DNA synthesis rates and fidelity in mammalian cells

Influence of aging and behavioral experience on expression of GluN1 splice variants of the NMDA receptor in prefrontal cortex of mice brain

Identification and quantitation of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites in vivo as biomarkers of oxidative stress

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