Index Catalog // ScholarsArchive@OSU

Age-related response of isolated rat hepatocytes to menadione and (R)-[alpha]-lipoic acid

Creator:: Graves, Jason T.
Abstract:: Age-related decline in the capacity of endogenous antioxidant systems complicates pharmaceutical use by the elderly by potentially increasing the toxicity of some compounds. Of particular interest is chemical detoxification via glutathione (GSH) and attendant GSH-requiring detoxification enzymes, e.g. GSH peroxidases (GPX) and GSH S-transferase (GST). These enzymes have been shown...
Resource Type:: Undergraduate Thesis

Development and broad application of a mass spectrometry based metabolomics platform

Creator:: Kirkwood, Jay Steven
Abstract:: Metabolomics is a comprehensive analysis of small molecules, or metabolites, in a system. Metabolomics is a hypothesis-generating experiment and offers an unbiased analysis of cell metabolism that can aid in the understanding of fundamental biological processes. Metabolomics is widely and broadly applicable in the biological sciences and has been used...
Resource Type:: Dissertation
Full Text:: , Maret Traber, Jane Ishmael, and Tory Hagen for your support and interest in my development as a

Chemical labeling methods and mass spectrometry of mitochondrial thiol proteomes

Creator:: Wang, Jing
Abstract:: Dysfunction of mitochondria has been linked to aging and the pathogenesis of many degenerative diseases. Aside from their primary function in energy production, mitochondria are considered as a major source and target of reactive oxygen and nitrogen species (ROS/RNS) in cells as well. The mitochondrial thiol proteome is a subset...
Resource Type:: Dissertation
Full Text:: . Thanks also to all the members who have served on my committee: Professors Douglas Barofsky, Tory Hagen

Control of p53 tumor suppressor and peroxiredoxin activity through shifts incellular redox balance

Creator:: Stoner, Christopher S.
Abstract:: Aerobic organisms have evolved many sensory mechanisms that allow response to oxidants in the environment. One area of interest is the relationship between the activity of the tumor suppressor protein p53 and the redox state of thioredoxin. Human p53 activity is severely compromised in budding yeast lacking thioredoxin reductase. Evidence...
Resource Type:: Dissertation
Full Text:: . Reactions were stopped by addition of 400 µl 1.5 M Na2CO3. Normalized β– galactosidase activity was

Exploring Potential Therapeutics Using a Drug Screening Platform in Drosophila melanogaster

Creator:: D'Haem, Maddie
Abstract:: Mechanisms of aging and age-related diseases are not completely understood in humans. Studying model organisms like Drosophila melanogaster, also known as the common fruit fly, can help humans better understand the aging process and diseases related to aging. From previous studies demonstrated in Drosophila, an accelerated aging model has been...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Tory Hagen, Committee Member, representing Biochemistry & Biophysics

Ibuprofen Treatment Causes NMDA and AMPA Receptor Hyperactivity in Female Wild Type and Heterozygous 5xFAD mice but not Males

Creator:: Rauenhorst, Jacob
Abstract:: With Alzheimer’s disease being the most prominent form of dementia, finding potential treatments for the disease is imperative. This study explored the non-steroidal anti-inflammatory drug ibuprofen as a potential treatment to normalize the hyperactive N-methyl-d-aspartate receptor (NMDAR) within the 5xFAD mice early in the disease pathology before cognitive decline. Female...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Tory Hagen, Committee Member, representing Department Biochemistry and Biophysics

Cellular mechanisms of muscle weakness and fatigability in individuals with multiple sclerosis

Creator:: Garner, Dena J. P.
Abstract:: Muscle weakness and fatigue are debilitating symptoms of multiple sclerosis (MS). Approximately 50% of muscle weakness and fatigue have been attributed to deficits within the peripheral nervous system, specifically mechanisms residing in the muscle. The goals of this study were to identify the cellular mechanisms of contraction within the muscle...
Resource Type:: Dissertation
Full Text:: members, Steve Hannigan- Downs, Tory Hagen, and Rebecca Johnson, who took the time to read and

Biomechanical Demands and Postural Control During Exercises Commonly Performed by Older Adults in Falls Prevention Programs

Creator:: Stutzenberger, Lyndsay R.
Abstract:: Exercise programs that are individualized and moderately challenge balance to address falls risk factors are recommended for preventing falls in community-dwelling older adults. Little is known regarding the biomechanical and postural control demands in exercises commonly performed in falls prevention programs. Twenty-two non-sedentary, healthy older adults (11 men, 11 women,...
Resource Type:: Dissertation
Full Text:: analysis, and review and revision of the manuscripts. Dr. Tory Hagen assisted with the design of the

Oxidative stress in amyotrophic lateral sclerosis : the role of cellular senescence and glutathione

Creator:: Beilby, Pamela R.
Abstract:: Amyotrophic lateral sclerosis (ALS) is a devastating neurological disorder characterized by neuromuscular junction decay, motor neuron death, progressive paralysis, and eventually death of the individual, usually by respiratory failure. Oxidative stress is a prominent hallmark of the disease and is often accompanied and exacerbated by mitochondrial dysfunction and neuroinflammation. This...
Resource Type:: Dissertation
Full Text:: , Kathy Magnusson, Barb Taylor, and Tory Hagen, who have provided guidance and encouragement

The effects of enhanced expression of the GluN2B (NR2B) subunit of the N-methyl-D-aspartate (NMDA) receptor on memory in aged animals

Creator:: Brim, Brenna L.
Abstract:: As the aging population continues to grow worldwide, age-related complications are becoming more apparent within the aging population. One of the first age-related complications to become apparent is age-associated memory impairment and it can make the elderly more dependent on caregivers early on. The N-methyl-D-aspartate (NMDA) receptor is important to...
Resource Type:: Dissertation

ScholarsArchive@OSU

Age-related response of isolated rat hepatocytes to menadione and (R)-[alpha]-lipoic acid

Development and broad application of a mass spectrometry based metabolomics platform

Chemical labeling methods and mass spectrometry of mitochondrial thiol proteomes

Control of p53 tumor suppressor and peroxiredoxin activity through shifts incellular redox balance

Exploring Potential Therapeutics Using a Drug Screening Platform in Drosophila melanogaster

Ibuprofen Treatment Causes NMDA and AMPA Receptor Hyperactivity in Female Wild Type and Heterozygous 5xFAD mice but not Males

Cellular mechanisms of muscle weakness and fatigability in individuals with multiple sclerosis

Biomechanical Demands and Postural Control During Exercises Commonly Performed by Older Adults in Falls Prevention Programs

Oxidative stress in amyotrophic lateral sclerosis : the role of cellular senescence and glutathione

The effects of enhanced expression of the GluN2B (NR2B) subunit of the N-methyl-D-aspartate (NMDA) receptor on memory in aged animals

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