Dendrimers are well-defined, polymeric nanomaterials currently being investigated for biomedical applications such as medical imaging, gene therapy, and tissue targeted therapy. Initially, higher generation (size) dendrimers were of interest because of their drug carrying capacity. However, increased generation was associated with increased toxicity. The majority of studies exploring dendrimer toxicity...
Inherent nanomaterial characteristics, composition,
surface chemistry, and primary particle size,
are known to impact particle stability, uptake, and
toxicity. Nanocomposites challenge our ability to predict
nanoparticle reactivity in biological systems if they
are composed of materials with contrasting relative
toxicities. We hypothesized that toxicity would be
dominated by the nanoparticle...
Inherent nanomaterial characteristics, composition,
surface chemistry, and primary particle size,
are known to impact particle stability, uptake, and
toxicity. Nanocomposites challenge our ability to predict
nanoparticle reactivity in biological systems if they
are composed of materials with contrasting relative
toxicities. We hypothesized that toxicity would be
dominated by the nanoparticle...
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toxicity of engineered silver
nanoparticles
Josephine A. Bonventre • Joseph B. Pryor •
BryanJ. Harper
Inherent nanomaterial characteristics, composition, surface chemistry, and primary particle size, are known to impact particle stability, uptake, and toxicity. Nanocomposites challenge our ability to predict nanoparticle reactivity in biological systems if they are composed of materials with contrasting relative toxicities. We hypothesized that toxicity would be dominated by the nanoparticle...
Cellulose is an abundant and renewable resource currently being investigated for utility in nanomaterial form for various promising applications ranging from medical and pharmaceutical uses to mechanical reinforcement and biofuels. The utility of nanocellulose and wide implementation ensures increasing exposure to humans and the environment as nanocellulose-based technologies advance. Here,...
The integration of rapid assays, large datasets, informatics, and modeling can overcome current barriers in understanding nanomaterial structure–toxicity relationships by providing a weight-of-the-evidence mechanism to generate hazard rankings for nanomaterials. Here, we present the use of a rapid, low-cost assay to perform screening-level toxicity evaluations of nanomaterials in vivo. Calculated...
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) metric of toxicity”.
Authors: BryanHarper, Dennis Thomas, Satish Chikkagoudar, Nathan Baker, Kaizhi
The integration of rapid assays, large datasets, informatics, and modeling can overcome current barriers in understanding nanomaterial structure–toxicity relationships by providing a weight-of-the-evidence mechanism to generate hazard rankings for nanomaterials. Here, we present the use of a rapid, low-cost assay to perform screening-level toxicity evaluations of nanomaterials in vivo. Calculated...
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diverse nanomaterials using the embryonic zebrafish (EZ)
metric of toxicity
BryanHarper . Dennis Thomas
Zinc oxide nanoparticles (ZnO NPs) are widely used in a variety of products, thus understanding their health and environmental impacts is necessary to appropriately manage their risks. To keep pace with the rapid increase in products utilizing engineered ZnO NPs, rapid in silico toxicity test methods based on knowledge of...
Zinc oxide nanoparticles (ZnO NPs) are widely used in a variety of products, thus understanding their health and environmental impacts is necessary to appropriately manage their risks. To keep pace with the rapid increase in products utilizing engineered ZnO NPs, rapid in silico toxicity test methods based on knowledge of...