Coibamide A is a methyl-stabilized cyclic depsipeptide with a lariat side chain that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups program based in Panama. Previous testing of this potent and selective growth-inhibitory agent in the National Cancer Institute (NCI) in vitro 60 human...
N-methyl-D-aspartate (NMDA) receptors are calcium-permeable ion channels
assembled from four subunits that each have a common membrane topology. The
intracellular carboxyl terminal domain (CTD) of each subunit varies in length, is least
conserved between subunits, and binds multiple intracellular proteins. We defined a
region of interest in the GluN2A CTD,...
Full Text:
Gaurav Bajaj a, AndrewM. Hau a, Peter Hsu a, Philip R. Gafken b,
Michael I Schimerlik c and Jane E
N-methyl-D-aspartate (NMDA) receptors are calcium-permeable ion channels
assembled from four subunits that each have a common membrane topology. The
intracellular carboxyl terminal domain (CTD) of each subunit varies in length, is least
conserved between subunits, and binds multiple intracellular proteins. We defined a
region of interest in the GluN2A CTD,...
Full Text:
Authors: Gaurav Bajaj, Ph.D.; AndrewMHau, Ph.D.; Peter Hsu, B.S.; Philip R Gafken, Ph.D.;
Michael I
N-methyl-D-aspartate (NMDA) receptors are calcium-permeable ion channels
assembled from four subunits that each have a common membrane topology. The
intracellular carboxyl terminal domain (CTD) of each subunit varies in length, is least
conserved between subunits, and binds multiple intracellular proteins. We defined a
region of interest in the GluN2A CTD,...
Coibamide A is an N-methyl-stabilized depsipeptide that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. Previous testing of coibamide A in the NCI in vitro 60 cancer cell line panel revealed a potent anti-proliferative response and "COMPARE-negative" profile indicative...
Many industries in California are difficult to decarbonize, making carbon capture and storage (CCS) essential to reach net zero. California has committed to deliver an enormous 100 thousand tons per year of carbon storage by 2045. Despite much interest in carbon sequestration, there are currently no active geologic carbon capture...
Writing within Discipline is a pedagogical model that aims to engage students in active learning and to develop critical thinking and writing skills within the norms of a particular discipline. However, lack of faculty time for grading writing products impedes its broader implementation. Web based peer review programs have been...
Robotic limbs have been shown to enable mobility in unstructured, real-world terrain; they allow robots to step around cluttered environments, scramble up hills, carry heavy loads, and even perform acrobatics. However, mechanical limbs cannot operate as a means for such dynamic locomotion if they are simply treated as general articulated...
With too many demands placed on too little water, the Klamath Basin and itsresidents - human and otherwise - are in dire need. There exists a significant opportunityfor mitigation in the purposeful conversion of seasonal wetlands to permanent wetlandsmanaged to increase baseline water storage levels in the Upper Basin. A...
Deforestation and loss of soil fertility are two forms of environmental degradation with global importance. Theories of environmental degradation commonly cited in public and academic discourse have historically emphasized the role of human populations and national economic development as being the primary drivers of environmental damage. This thesis utilizes quantitative...