Liver X receptor (LXR), farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor (PPAR) are adopted orphan nuclear receptors that function as lipid sensors. These receptors respond to cellular lipid levels and regulate the expression of target gene. Previously, it was demonstrated that low doses of chlordecone (CD) pretreatment disturbed exogenous...
Billions of pounds of bisphenol A (BPA) are produced annually around the globe for the manufacture of numerous consumer products, including polycarbonate food and water containers, the protective resin linings of food cans, thermal printing paper, and dental fillings. BPA exposure during nervous system development has been associated with learning...
Two Oregon reservoirs contaminated by different mercury
sources were compared for mercury distribution in sediment and
bioaccumulation by fish. The average mercury concentration in
the sediment of Cottage Grove reservoir (0.67 ± 0.05 μg/g dry
wt) was higher than for Dorena Reservoir (0.12 ± 0.01 μg/g dry
wt). Sediment mercury...
Alkaline phosphatase (ALP) is an enzyme present in intestinal mucosa, bile, bone and renal tubule cells. Bile acids have been shown to decrease ALP activity from bone and kidney but not those from intestinal origin. This action can be mimicked in serum and peritoneal fluid samples by the use of...
Solid-state esophageal manometry was used to study physiology of the normal llama esophagus. Esophageal baseline pressures, esophageal response to water swallows and to balloon distention, and other motor activity of the esophagus during experiments were measured throughout the entire length of the esophagus. Gross and histologic anatomy, muscle fiber type...
The isoprenoid pathway is one of the major biosynthetic pathways of secondary metabolites. Isoprenoids with a C₂₀ skeleton are known as diterpenoids and are derived from the common precursor, geranylgeranyl diphosphate (GGPP). This dissertation describes approaches to discover the diterpene synthase enzymes which provide the backbone structures for pleuromutilin and...
Wavelet analysis is an analytical and modeling tool for optimizing sampling efficiency and accuracy, particularly in the context of designing long-term, large-scale monitoring plans. As a pattern analysis method that accommodates and preserves non-stationarity, wavelet analysis provides novel visualization and analytical capabilities for increased insight into interactions between multi-scalar heterogeneous...
Many trace elements (e.g., Zn, Cd, Mo) are essential phytoplankton micronutrients, making them crucial to the marine ecosystem and ultimately the carbon cycle. Because of this association trace metals are also utilized in paleoceanographic studies (e.g., Mo, Cd). However, not much is known about what controls the cycling of these...
Corneal ulcers are one of the most common eye conditions of the horse, with potentially serious complications such as loss of vision or the eye itself. They are extremely painful due to the large number of sensory nerve endings found in the cornea. Horses frequently show signs of ophthalmic pain...