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  • A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

    Creator:
    Myzak, Melinda C.
    Abstract:
    Targeting the epigenome, including the use of histone deacetylase (HDAC) inhibitors, is a novel strategy for cancer chemoprevention. Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a potent inducer of Phase 2 detoxification enzymes and inhibits tumorigenesis in animal models. SFN also has a...
    Resource Type:
    Dissertation
    Full Text:
    Novel Mechanism of ChemoDrevention by SulforaDhane: Inhibition of Histone Deacetylase. Abstract

  • Dietary organosulfur and organoselenium compounds as HDAC inhibitors

    Creator:
    Nian, Hui
    Abstract:
    Histone deacetylase (HDAC) inhibitors have the potential to de-repress epigenetically silenced genes in cancer cells, leading to cell cycle arrest and apoptosis. Dietary HDAC inhibitors derived from natural phytochemicals are promising anticancer agents. In this thesis, metabolites from natural organosulfur and organoselenium compounds, i.e. allyl mercaptan (AM), β-methylselenopyruvate (MSP) and...
    Resource Type:
    Dissertation
    Full Text:
    :      Roderick H. Dashwood     Histone  deacetylase  (HDAC)  inhibitors  have  the  potential  to  de‐repress