In Heart of Darkness and The Good Soldier, Joseph Conrad and Ford Madox Ford employ the narrative subjectivity inherent in their Impressionist technique to provide insight into the often-irrational processes through which political and individual identities are constructed through narrative. Contrary to traditional readings of Impressionism as a strictly aesthetic...
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Microsoft Word - FINAL THESIS!!!!!.docx
Molly
Jones
In Heart of Darkness and The Good Soldier, Joseph Conrad and Ford Madox Ford employ the narrative subjectivity inherent in their Impressionist technique to provide insight into the often-irrational processes through which political and individual identities are constructed through narrative. Contrary to traditional readings of Impressionism as a strictly aesthetic...
Evidence-based interventions (EBIs), which demonstrate efficacy in research settings, are rarely sustained when implemented in public health organizations. Rather, EBIs are often de-adopted - potentially undermining the positive benefits of the EBIs for the communities that access them. The lack of sustainability is particularly troubling among public health organizations that...
Specialized or secondary metabolism is a collection of pathways and small molecules that, while beneficial to an organism, are not strictly necessary for survival. Plants use secondary metabolites to, among other things, attract pollinators, defend against biotic and abiotic stressors, and form symbioses. Natural products from plants have seen an...
Gene expression is largely regulated by the binding of transcription factors to short sequences of DNA (transcription factor binding sites) to drive or repress transcription of an adjacent gene. Identifying the key transcription factor binding sites associated with a particular biological outcome provides an avenue for tailored transcriptional regulation in...
Gene regulation is a complex mechanism that controls the spatial and temporal expression of genes in a living cell. My dissertation studies focus on two problems. First, tissue-specific gene expression prediction from DNA sequence and chromatin state, and second, the accurate discovery of small over-represented regulatory circuits in gene regulatory...
Null networks are a type of random graph that is favored for the analysis of a wide variety of real-world networks, including gene-regulatory networks, food webs, and species co-occurrence matrices. As a hypothesis-generating tool, null networks are invaluable because they can reveal network motifs and unusual large-scale properties of networks...
Osmotic stress is a common challenge faced by organisms in environments with variable salinity or aridity. Understanding the evolutionary mechanisms underlying adaptation to osmotic stress may have wide applications, including management of populations experiencing climate change, or engineering industrial organisms involved in processes such as fermentation. While Saccharomyces cerevisiae is...
Immune system development during prenatal and early-life periods are essential for healthy development. Environmental and nutritional factors during these periods have strong influences on immune development and can have impacts on disease susceptibility for an individual throughout adulthood. Globally, hundreds of millions of people experience elevated environmental exposure to arsenic,...