Objectives: Nitrate, found abundantly in green leafy vegetables, may improve exercise performance by increasing the availability and utilization of metabolic fuels that require less oxygen for energy production. However, it is not known if this performance effect occurs at the peak exercise intensity. We hypothesize that supplemental nitrate treatment will...
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NormanHord, Mentor, representing School of Biological and Population Health Sciences
A decline in the oxygen cost of exercise enhances exercise tolerance and performance. Substantial research has shown that dietary nitrate lowers the oxygen cost of exercise in sedentary humans; however, the metabolic determinants regarding how dietary nitrate influences oxygen consumption in skeletal muscle is not known. We addressed this gap...
Osteoporosis is a common metabolic bone disease, affecting a third of women and a fifth of men over age 65. In the US, annual health care costs associated with osteoporosis are estimated to be over $20 billion. Osteoporosis is associated with increased fracture risk, which has been demonstrated to predict...
The presence of nitrates and nitrites in food is associated with an increased risk of gastrointestinal cancer and, in infants, methemoglobinemia. Nitrites are produced endogenously through the oxidation of nitric oxide and through a reduction of nitrate by commensal bacteria in the mouth and gastrointestinal tract. Despite the physiologic roles...