Intravenous regional limb perfusion (IVRLP) with tiludronate is a commonly used treatment for distal limb orthopedic disease in horses, but doses and protocols are anecdotal. IVRLP exposes articular cartilage within the perfused area to tiludronate, raising concerns about safety of this treatment, as high tiludronate concentrations (≥19mg/L) were harmful for...
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Anecdotal accounts of tiludronate administration via intravenous regional limb
perfusion (IVRLP) exist despite a lack of information regarding safety for synovial
structures in the perfused area. The objective of this study was to determine whether
tiludronate concentrations in synovial structures after IVRLP with low dose (0.5 mg,
LDT) or high...
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Interests
The authors declare there are no competing interests.
Author Contributions
• BarbaraG. Hunter
Anecdotal accounts of tiludronate administration via intravenous regional limb
perfusion (IVRLP) exist despite a lack of information regarding safety for synovial
structures in the perfused area. The objective of this study was to determine whether
tiludronate concentrations in synovial structures after IVRLP with low dose (0.5 mg,
LDT) or high...
Full Text:
Knotty T4 low dose Treatment Key TP total synovial fluid protein in g/dl
7 Max T5 high dose horse name
Anecdotal accounts of tiludronate administration via intravenous regional limb
perfusion (IVRLP) exist despite a lack of information regarding safety for synovial
structures in the perfused area. The objective of this study was to determine whether
tiludronate concentrations in synovial structures after IVRLP with low dose (0.5 mg,
LDT) or high...