Experimental infection of mice with Candida albicans leads
to significant suppression of cell mediated immune responses.
We have characterized the nature of this candida-induced
suppression with formalin killed Candida albicans (FKCA) in the
yeast and mycelia' phase. Mice (BALB/c or C57B1/6J) treated
with FKCA exhibited a reduction in the T-cell...
Exposure to TCDD suppresses the generation of immune responses through unknown mechanisms. Interestingly, TCDD enhances inflammatory responses to various stimuli. The goal of the studies presented in this thesis was to examine the role of hyperinflammation in TCDD-induced immunotoxicity. Previously we observed an increase in Mac-1⁺ cells in the spleen...