N-methyl-D-aspartate (NMDA) receptors are calcium-permeable ion channels
assembled from four subunits that each have a common membrane topology. The
intracellular carboxyl terminal domain (CTD) of each subunit varies in length, is least
conserved between subunits, and binds multiple intracellular proteins. We defined a
region of interest in the GluN2A CTD,...
Full Text:
Gaurav Bajaj a, Andrew M. Hau a, Peter Hsu a, Philip R. Gafken b,
Michael I Schimerlik c and JaneE
N-methyl-D-aspartate (NMDA) receptors are calcium-permeable ion channels
assembled from four subunits that each have a common membrane topology. The
intracellular carboxyl terminal domain (CTD) of each subunit varies in length, is least
conserved between subunits, and binds multiple intracellular proteins. We defined a
region of interest in the GluN2A CTD,...
Full Text:
Jersey
To whom correspondence should be addressed:
JaneE. Ishmael, Ph.D.
Department of
N-methyl-D-aspartate (NMDA) receptors are calcium-permeable ion channels
assembled from four subunits that each have a common membrane topology. The
intracellular carboxyl terminal domain (CTD) of each subunit varies in length, is least
conserved between subunits, and binds multiple intracellular proteins. We defined a
region of interest in the GluN2A CTD,...
Myosins are actin-based molecular motors that may have specialized trafficking and contractile functions in cytoskeletal compartments that lack microtubules. The postsynaptic excitatory synapse is one such specialization, yet little is known about the spatial organization of myosin motor proteins in the mature brain. We used a proteomics approach to determine...
Coibamide A is an N-methyl-stabilized depsipeptide that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. Previous testing of coibamide A in the NCI in vitro 60 cancer cell line panel revealed a potent anti-proliferative response and "COMPARE-negative" profile indicative...
Before the arrival of Euro-Americans, the inland Pacific Northwest was settled by native
people whose frequent intentional burning of the landscape promoted open stands
dominated by large fire-resistant ponderosa pine. Fire suppression for nearly a century,
livestock grazing, and logging of the largest trees has resulted in forests characterized by...
Seedlings of Gaultheria shallon, Pseudotsuga menziesii, Rhododendron macrophyllum and Tsuga heterophylla were grown together in the greenhouse in soils from three young managed Douglas-fir forests in the Oregon Coast Range. The main objectives were 1 )to evaluate the ability of ericaceous plants and overstory conifers to share compatible mycorrhizal fungi...
One fundamental concern in conservation biology is species abundance. For many taxa, however, these data are costly to obtain via direct observation and thus limited in geographic or temporal scope. Very high-resolution satellite imagery provides a means to address these limitations and provide remotely-sensed counts of large, colonial species. We...
This investigation examines The Jetsons’ vision of the future and tracks to what extent the content of the show is relevant to the modern era, both technologically and socially. Much of the dazzling technology in the show feels familiar, and most of it is either already available or is in...
Natural ground color is useful for reference maps as well as maps where a realistic representation of the Earth's surface matters. Natural color schemes are less likely to be misinterpreted, as opposed to hypsometric color schemes, and are generally preferred by map readers. The creation of natural-color maps was once...