Exposure to arsenic early in life has been associated with increased risk of several chronic diseases and is believed to alter epigenetic programming in utero. In the present study, we evaluate the epigenome-wide association of arsenic exposure in utero and DNA methylation in placenta (n=37), umbilical artery (n=45) and human...
The Generation IV Very High Temperature Reactor (VHTR) design is being actively
studied in various countries for application due to its inherent passive safe design,
higher thermal efficiencies, and proposed capability of providing high temperature
process heat. The pebble bed core is one of two core designs used in gas...
Downward flow opposing mixed convection conditions have been studied using the FLUENT CFD code. This work was comprised of two primary objectives. The first was to study core channel flow reversal susceptibility in the Gas Reactor Test Section (GRTS) at low flow conditions. The second objective was the development of...
The size, shape, and stability of a species’ dietary niche can both influence and reflect a variety of biological patterns, including species interactions, extinction risk, and ecosystem function. This is particularly apparent when dietary changes manifest at ecosystem and clade scales to profoundly affect macroecological and macroevolutionary trajectories. However, many...
The purpose of this multi-case study was to explore the stories and lived experiences of Native American police chiefs who have faced the systemic conflicts and challenges created between Native American tribal policing and an opposing U.S. legal system. It sought to understand the essence of tribal police chiefs’ experiences...
The objective of this study was to compare light wood framing and traditional timber
framing quantitatively through environmental impact assessment and load path analysis. This
research was inspired by a traditional timber frame structure constructed in Vermont in 2011, and
the design of structures considered within reflect the general characteristics...
The primary goal of any model is to emulate, as closely as possible, the desired behavioral phenomena of the real system but still maintain some tangible qualities between the parameters of the model and the system response. In keeping with this directive, models by their very nature migrate towards increasing...
This study examined associations between participation in voluntary out-of-school programs (e.g., scouting, Boys' and Girls' Clubs, 4-H, YMCA/YWCA) in adolescence and four negative outcomes: school dropout, early sexual activity, delinquency, and drug use. A prospective longitudinal design had collected four waves of interview data on a national sample of 15,000...
Anti-predator behaviors like vigilance or hiding come at the expense of other fitness increasing behaviors such as foraging. To compensate for this trade-off, prey assess predation risk and modify the frequency of anti-predator behaviors according to the likelihood of the threat. In this study, we tested the ability of house...
CD8⁺ T cells are responsible for killing cells of the body that have become infected or oncogenically transformed. In order to do so, effector CD8⁺ T cells must recognize their cognate antigenic peptide bound to a MHC class I molecule that has been directly presented by the target cell. Due...