Various simple mathematical models have been used to investigate dengue transmission. Some of these models explicitly model the mosquito population, while others model the mosquitoes implicitly in the transmission term. We study the impact of modeling assumptions on the dynamics of dengue in Thailand by fitting dengue hemorrhagic fever (DHF)...
The HIV pandemic continues to impose enormous morbidity, mortality and economic burdens across the globe. Simultaneously, innovations in antiretroviral therapy, diagnostic approaches and vaccine development are providing novel tools for treatment-as-prevention and prophylaxis. We developed a mathematical model to evaluate the added benefit of an HIV vaccine in the context...
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targets and HIV vaccination
across 127 countries
Jan Medlocka,1, Abhishek Pandeyb, Alyssa S. Parpiab
The HIV pandemic continues to impose enormous morbidity, mortality and economic burdens across the globe. Simultaneously, innovations in antiretroviral therapy, diagnostic approaches and vaccine development are providing novel tools for treatment-as-prevention and prophylaxis. We developed a mathematical model to evaluate the added benefit of an HIV vaccine in the context...
Full Text:
countries
Jan Medlocka,1, Abhishek Pandeyb, Alyssa S. Parpiab, Amber Tangb, Laura A. Skripb,
and Alison P
Background
In the weeks following the first imported case of Ebola in the U. S. on September 29, 2014, coverage of the very limited outbreak dominated the news media, in a manner quite disproportionate to the actual threat to national public health; by the end of October, 2014, there were...
Background
In the weeks following the first imported case of Ebola in the U. S. on September 29, 2014, coverage of the very limited outbreak dominated the news media, in a manner quite disproportionate to the actual threat to national public health; by the end of October, 2014, there were...
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, Fereshteh Nazari1,
Kamaldeen Okuneye1, Mary L. Ross1, Claudia Rodriguez1, Jan Medlock3, David Ebert2,
Carlos
Impact of reproductive processes upon female health has yielded conflicting results; particularly in relation to the role of
reproduction-associated stress. We used the viviparous tsetse fly to determine if lactation, birth and involution lead to
damage from oxidative stress (OS) that impairs subsequent reproductive cycles. Tsetse females carry an intrauterine...
Impact of reproductive processes upon female health has yielded conflicting results; particularly in relation to the role of
reproduction-associated stress. We used the viviparous tsetse fly to determine if lactation, birth and involution lead to
damage from oxidative stress (OS) that impairs subsequent reproductive cycles. Tsetse females carry an intrauterine...
Full Text:
Michalkova V, Benoit JB, Attardo GM, Medlock J, Aksoy S (2014) Amelioration of
Reproduction-Associated
Human African trypanosomiasis (HAT), transmitted by tsetse flies, has historically infected hundreds of thousands of individuals annually in sub-Saharan Africa. Over the last decade, concerted control efforts have reduced reported cases to below 10,000 annually, bringing complete elimination within reach. A potential technology to eliminate HAT involves rendering the flies...
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A. Gilbert1,2*, Jan Medlock3, Jeffrey P. Townsend4,5,6, Serap Aksoy2, Martial
Ndeffo Mbah1,2¶, and
Human African trypanosomiasis (HAT), transmitted by tsetse flies, has historically infected hundreds of thousands of individuals annually in sub-Saharan Africa. Over the last decade, concerted control efforts have reduced reported cases to below 10,000 annually, bringing complete elimination within reach. A potential technology to eliminate HAT involves rendering the flies...
Full Text:
Jennifer A. Gilbert1,2*, Jan Medlock3, Jeffrey P. Townsend4,5,6, Serap Aksoy2,
Martial Ndeffo Mbah1,2
Identification of the optimal vaccine allocation for the control of influenza requires consideration of uncertainty arising from numerous unpredictable factors, including viral evolution and diversity within the human population’s immunity as well as variation in vaccine efficacy. The best policy must account for diverse potential outcomes based on these uncertainties....
