Immune-mediated diseases are a frequent cause of morbidity and mortality in canine patients. Treatments currently involve generalized suppression of the immune system, and corticosteroids are often used as a first-line agent. While often effective, corticosteroids are unlikely to induce remission without substantial side effects. Second-line immunosuppressive agents may be effective...
Osteosarcoma (OSA) is a primary malignant bone tumor sarcoma that occurs in dogs as well as people and has aggressive biologic behavior with devastating consequences. Because of the similarities in morphology and prognosis, OSA in dogs represents an effective model for the equivalent disease in humans. Mesenchymal stem cells (MSCs)...
Osteosarcoma (OS) is the most common primary bone tumor in both humans and dogs, occurring approximately 10 times more frequently in dogs. OS is a highly aggressive neoplasm with evidence of metastasis often found at the time of diagnosis. Long-term survival in afflicted dogs continues to remain low despite aggressive...