The myeloid-specific transcription factor, CCAAT/enhancer-binding protein epsilon (C/EBPε) is a critical mediator of myelopoiesis. Mutation of this gene is responsible for neutrophil-specific granule deficiency in humans, a condition that confers susceptibility to Staphylococcus aureus infection. We found that C/EBPε-deficient mice are severely affected by infection with S. aureus, and C/EBPε...
Over a 3.5-year period, 4 Rocky Mountain goats (Oreamnos americanus), housed at a single facility, developed clinical disease attributed to infection by Caprine arthritis encephalitis virus (CAEV). Ages ranged from 1 to 10 years. Three of the goats, a 1-year-old female, a 2-year-old male, and a 5-year-old male, had been...
Randomized trials are the gold standard for the clinical assessment of a new treatment
compared to a placebo or standard of care. Often in clinical trials, patients are
accrued sequentially rather than all at once. Thus, the data from such a trial becomes
available sequentially to the researcher. Monitoring and...
Adult onset progressive alopecia and leukotrichia developed in 2 registered black Angus cows, aged 6 and 7
years. Histopathologic findings in skin were prominent melanin clumping and degeneration of matrix cells with formation
of giant multinucleate cells within hair bulbs, accompanied by peribulbar melanin incontinence and fibrosis and dystrophic
hair...
Hmong women in the U.S. have low rates of breast and cervical cancer screening, and the factors that influence screening in this population are not well-understood. This qualitative study explored family and clan influences on Hmong women’s breast and cervical cancer screening attitudes and behavior. We conducted in-depth interviews with...
Background: Considering the pharmacokinetic and pharmacodynamic aspects of different medications, it is plausible that the age of a smoker could affect the half-life of these drugs. The aim of this study was to compare the effectiveness of smoking cessation drugs (nicotine replacement therapy, bupropion, and varenicline) used either in isolation...
The efficacy of DNA extraction protocols can be highly dependent upon both the type of sample being investigated and the types of downstream
analyses performed. Considering that the use of new bacterial community analysis techniques (e.g., microbiomics, metagenomics) is becoming
more prevalent in the agricultural and environmental sciences and many...
The Columbia River Gillnetter is the pilot of the Lower Columbia River commercial fishing industry, keeping fishermen and the public in touch with today's important issues.
Serotonin regulates many intestinal motor and sensory functions. Altered serotonergic metabolism has been described in human gastrointestinal diseases. The objective of our study was to compare expression of several components of the serotonergic system [serotonin (5-HT), serotonin reuptake transporter protein (SERT), tryptophan hydroxylase-1 (TPH-1), 5-HT receptor[subscript 2B] (5-HT[subscript 2B])] and...