Integrase catalyzes insertion of a retroviral genome into the host chromosome. Following reverse transcription, integrase binds specifically to the ends of the duplex retroviral DNA, endonucleolytically cleaves two nucleotides from each 3'-end (the processing activity), and inserts these ends into the host DNA (the joining activity) in a concerted manner....
Science is difficult for even its researchers to understand. Science journalists must understand scientific discoveries well enough to write clear, accurate explanations of scientific discoveries for laypeople. A sense of ethical judgment will help journalists ensure that their accounts are reliable and appropriate. Responsible science journalists will maintain a working...
Over the past decade, it has come to light that many published scientific findings cannot be reproduced. This has led to the replication crisis in science. Many researchers feel that they can no longer trust much of what they read in scientific journals, and the public is becoming ever more...
In the Capabilities Approach literature “capabilities” are the real freedoms individuals possess to achieve certain “functionings,” which are the doings and beings that constitute a good life. I argue that this approach requires, or at least can benefit from, an account of the psychosocial mechanisms involved in capability limitation. The...
In order to better characterize linker histone interactions with DNA, avian erythrocyte-specific linker H5 and the trypsin-resistant globular domain of H5 (GH5) were used in DNA binding studies. To begin, H5 displayed a considerably higher binding
affinity for DNA than the isolated globular domain (GH5), supporting the importance of the...
In the contemporary U.S., the state, through the Legislative Assembly, the State Board of
Education, and the Department of Education, sets policies for K-12 education. These include goals
and standards that affect the kinds of influences local officials, parents, and students can have
on various education programs, required and elective...
Increasingly fishery managers are expected to take an ecosystem approach to fisheries management that accounts for the interrelationships of target species as well as non-target species and habitat. Fishery managers would benefit from coupled ecological-economic models that includes both the human and ecological aspects of the fishery and incorporates them...
This thesis develops recursion formulas for least-squares
data smoothing with regard to four classes of functions: linear,
quadratic, exponential and trigonometric, which in a linear fashion
involve 2, 3, 2 and 2 parameters respectively. The term recursion
implies here that the estimates for the parameters of the preceding
fit are...