This thesis describes 1) development of a gastric retention device (GRD) to
increase gastric retention time of certain drugs, 2) product formulations of an immediate
release itraconazole and controlled-release ketoprofen. GRD was fabricated from crosslinked
carbohydrate polymers. Rate and extent of hydration of the film in water and in
simulated...
Object categorization is one of the fundamental topics in computer vision research. Most current work in object categorization aims to discriminate among generic object classes with gross differences. However, many applications require much finer distinctions. This thesis focuses on the design, evaluation and analysis of learning algorithms for fine- grained...
Despite the advance of biomedical science, infectious diseases remain one of the number one killers in the world. They claim the lives of millions of people annually, particularly in underdeveloped and developing countries. In fact, more than 32% of the health burden in Africa is caused by infectious diseases, e.g.,...
A promising formulation of glipizide comprising compression of four-layer coated beads into tablets which has advantages of providing a lag time (~ 2 hours) before drug release, retaining sustained-release characteristics, and providing approximately zero-order drug release, with drug release nearly independent of paddle speeds of 50 and 100 rpm during...
Full Text:
71.25 g of sugar beads
overcoated with 2.5 g of glipizide and 3.75 g of solid ethylcellulose
In this project, we have investigated three different techniques for plagiarism detection and have compared its effectiveness against that of an unaided human grader. The techniques investigated were word frequency analysis, sentence inclusion analysis and sub string inclusion analysis. We found that a combination of word frequency analysis and sub...
This dissertation describes formulation of a gastric retention device (GRD) and sustained release (SR) hydrochlorothiazide beads at Oregon State University. Formulation condition and amounts of excipients had significant influence on characteristic of the GRD. The GRD containing SR hydrochlorothiazide beads was employed to assess bioavailability/bioequivalency study in healthy subjects. An...
In this study, I investigate how target value uncertainty may lead to acquirer mispricing of an acquisition target and how the mispricing may be a determinant of goodwill impairment. To the extent the mispricing leads to both high and low industry-adjusted purchase price multiples (PPMs are my proxies for overpayment...
This thesis describes in vitro and in vivo evaluation of a gastric retention formulation (GRF) developed at Oregon State University. The formulation was prepared from xanthan gum and locust bean gum as gelling agents and other formulation ingredients were added, then it was originally vacuum oven dried. The effect of...