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  • Three Sites are Better than One : Exploring Multivalency in LC8 Binding Partners

    Creator:
    Clark, Sarah A.
    Abstract:
    Hub proteins bind a large number of partners to facilitate structural changes and downstream protein interactions. LC8, a highly conserved protein homodimer, is a unique hub that regulates the activity of proteins in a wide range of cellular processes by binding to intrinsically disordered regions. With many of these systems,...
    Resource Type:
    Dissertation
    Full Text:
    Karplus’ lab, I helped develop the program the Ensemblator, a highly useful tool that enables global and

  • Analyses of noncanonical DNA structures

    Creator:
    Khuu, Patricia A.
    Abstract:
    The structural polymorphic nature of DNA has been long been recognized since the model of the right-handed B-DNA duplex proposed by James Watson and Francis Crick was accepted. Its malleability is thought to be critical in protein recognition and manipulation. In particular, it can form Holliday junctions, four-way DNA structural...
    Resource Type:
    Dissertation
    Full Text:
    Patricia A. Khuu for the degree of Doctor of Philosophy in Biochemistry and Biophysics presented on June

  • Measuring protein metal binding via mass spectrometry : copper, zinc superoxide dismutase and amyotrophic lateral sclerosis

    Creator:
    Rhoads, Timothy W.
    Abstract:
    Amyotrophic lateral sclerosis (ALS) is a devastating disease characterized by the progressive degeneration of motor neurons. Dominantly-inherited mutations to the antioxidant enzyme Cu,Zn superoxide dismutase (SOD1) cause 3-6% of all ALS cases. The complete mechanism behind the toxicity of mutant SOD1 remains unclear, although significant evidence points to aberrant or...
    Resource Type:
    Dissertation
    Full Text:
    : Joseph S. Beckman Amyotrophic lateral sclerosis (ALS) is a devastating disease characterized by

  • Effects of Predator Introductions on Population and Community Dynamics

    Creator:
    Ingeman, Kurt E.
    Abstract:
    There is increasing awareness that human activities are altering the ways that natural systems operate and that local shifts in species composition and abundance can lead to abrupt and irreversible global change. Therefore, understanding the processes that buffer biological communities from critical shifts and how our actions affect natural stabilizing...
    Resource Type:
    Dissertation
    Full Text:
    . I was very fortunate to have a graduate representative, Paul Jepson, with a background in

  • Comparing Ectomycorrhizal Communities of Understory Giant Chinquapin (Chrysolepis chrysophylla) and Overstory Pinaceae Trees in a Mixed Conifer Forest in Central Oregon

    Creator:
    Longway, Lucas J.
    Abstract:
    Giant chinquapin (Chrysolepis chrysophylla) is an evergreen hardwood often found as a shrubby understory component of coniferous forests in the Pacific Northwest United States. Due to its ability to sprout quickly after disturbances such as fire and logging it is often viewed as a pest by forest managers. Like its...
    Resource Type:
    Masters Thesis
    Full Text:
    Chinquapin (Chrysolepis chrysophylla) and Overstory Pinaceae Trees in a Mixed Conifer Forest in Central

  • Mitigating cyanobacterial harmful algae blooms : the role of plant humics

    Creator:
    Theis, Susan A. F.
    Abstract:
    Cyanobacterial harmful algae blooms (cyanoHABs) are a growing concern worldwide due to damage of ecosystems and threats to human health. Previous research indicates that plant humics from aquatic and wetland vascular plants are effective inhibitors of cyanobacterial metabolism and growth and may be useful as control agents for mitigating cyanoHABs....
    Resource Type:
    Masters Thesis
    Full Text:
    : ____________________________________________ Allen J Milligan Abstract: Cyanobacterial harmful algae blooms (cyanoHABs) are a

  • Semiparametric marginal and mixed models for longitudinal data

    Creator:
    Tsai, Guei-Feng
    Abstract:
    This thesis consists of three papers which investigate marginal models, nonparametric approaches, generalized mixed effects models and variance components estimation in longitudinal data analysis. In the first paper, a new marginal approach is introduced for high-dimensional cell-cycle microarray data with no replicates. There are two kinds of correlation for cell-cycle...
    Resource Type:
    Dissertation
    Full Text:
    thesis. In addition, I am grateful to my committee members, Dr. Paul A. Murtaugh from the Statistics

  • Indirect effects of fishing on predators and their prey

    Creator:
    Stallings, Christopher Derek
    Abstract:
    Predators are fundamentally important for regulating and driving prey population dynamics as well as structuring ecological communities. Over-exploitation of marine resources has caused dramatic depletions of predatory fish species and shifts in marine community composition, with attendant declines in productivity and diversity of marine ecosystems. Despite the important ramifications of...
    Resource Type:
    Dissertation
    Full Text:
    their Prey Abstract approved: ___________________________ Mark A. Hixon Predators

  • Evolutionary history and speciation of the genus Tragopan

    Creator:
    Islam, Kamal
    Abstract:
    A study of the phyletic relationships among five species of tragopans and an outgroup, the Blood Pheasant (Ithaginis cruentus), was conducted from 1987 to 1991. Biochemical, behavioral, and external morphologic characteristics were compared. A cladistic approach was used to compare the behavioral, biochemical, and external morphologic data collectively, as different...
    Resource Type:
    Dissertation
    Full Text:
    technical assistance: Bruce E. Coblentz, Harold N. Engel, Paul L. Farber, Paul A. Johnsgard, and Robert D

  • Evaluating Middle School Climate Curricula Using Best Practices and The Next Generation Science Standards

    Creator:
    van Breemen, Megan
    Abstract:
    Climate change remains controversial and misunderstood, despite the consensus among climate scientists that recent climate change is anthropogenic. Many American adults do not agree with or do not understand this scientific consensus, suggesting a disconnect in science communication or a distrust in science. This disconnect may begin in formal education...
    Resource Type:
    Masters Thesis
    Full Text:
    or do not understand this scientific consensus, suggesting a disconnect in science communication or