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  • Assessing an Adult Zebrafish Model for In Vivo Delivery of Morpholino Oligomers

    Creator:
    Kim, Joseph Y.
    Abstract:
    Antisense morpholino oligomers are synthetic macromolecules can modify gene expression. While these compounds have great potential to treat a broad range of human diseases, they suffer from poor cellular delivery. Conjugating cell-penetrating peptides onto these morpholinos is one option of addressing delivery, however development remains slow due to the cost...
    Resource Type:
    Honors College Thesis
    Full Text:
    Morpholino Oligomers by Joseph Yoojong Kim A THESIS submitted to

  • Mining Temporal Patterns for Prediction: A Mixed-Integer Programming Approach

    Creator:
    Mansourifard, Farzaneh
    Abstract:
    In the past two decades, the advancement in data collection and storage have led to the accumulation of complex datasets. Consequently, various industries have sought data-driven solutions to predict and detect anomalies. Temporal patterns have emerged as potential features in prediction models that could improve the performance of the identification...
    Resource Type:
    Masters Thesis
    Full Text:
    : Joseph Agor In the past two decades, the advancement in data collection and storage have led to the

  • Sustainable building design framework : an integrated approach

    Creator:
    Piacenza, Joseph R.
    Abstract:
    This paper combines two research publications working toward the development of an integrated framework for commercial sustainable building design. Current methodologies utilize a traditional architectural top-down approach to sustainable building design practices that consumes financial and temporal resources early in the design process. By identifying the array mechanical subsystems required...
    Resource Type:
    Masters Thesis
    Full Text:
    Joseph R. Piacenza III 349 Batcheller Hall Email: piacenzj@engr.orst.edu Irem Y. Tumer Ph.D

  • Mechanical engineering design across cultures : a method of designing for cultures

    Creator:
    Van Bossuyt, Douglas L.
    Abstract:
    Mechanical design is often based on formal methodologies such as Quality Function Deployment. Techniques to quantitatively account for attractability, sensory perception, and affective design have been successfully incorporated into these methods and are receiving growing acceptance across many industries. Although the adoption of these methods marks a large improvement for...
    Resource Type:
    Masters Thesis
    Full Text:
    : Mechanical Engineering Design Across Cultures: A Method of Designing for Cultures Abstract approved: Joseph

  • Measuring Instrument Precision Estimation in Destructive Testing

    Creator:
    Sunil Raj, Sayooj
    Abstract:
    The variability introduced into measurements by a measuring instrument is referred to as measurement instrument precision. Experimental procedures and analysis methods exist when measurements are repeatable and can be repeated on the same item. However, when the measurements are destructive and repeated measurements are not possible, estimating measuring instrument precision...
    Resource Type:
    Masters Thesis
    Full Text:
    : ______________________________________________________ David S Kim Variability introduced into measurements by a measuring instrument is

  • Selecting Probability Distributions for Use in Complex Discrete Event Simulation Models

    Creator:
    Moria, Eyad A.
    Abstract:
    In discrete event simulation, probability distributions are used as models of various unpredictable system components. The times between equipment failures and job processing times are examples of such random system components. The commonly recommended and taught practice for selecting a probability distribution to represent a random component is a multistep...
    Resource Type:
    Masters Thesis
    Full Text:
    approved: ______________________________________________________ David S. Kim In discrete event

  • A framework for assessing and improving the resilience of complex engineered systems during the early design process

    Creator:
    Mehrpouyan, Hoda
    Abstract:
    As modern systems continue to increase in size and complexity, they pose significant safety and risk management challenges. System engineers and much of the government research efforts are focused on understanding the attributes and characteristics that emerge from the interactions of components and subsystems. As a result, the objective of...
    Resource Type:
    Dissertation
    Full Text:
    Early Design Process Abstract approved: Irem Y. Tumer, Christopher J. Hoyle As modern systems

  • An investigation of multiphase flow in complex microchannel geometries for hemodialysis systems using residence time distribution analysis

    Creator:
    Coblyn, Matthew Y.
    Abstract:
    There are approximately 2.2 million cases of End-stage Renal Disease (ESRD) worldwide and current hemodialysis treatment is costly and ultimately insufficient compared to kidney transplantation. There is a strong need to arrive at a better solution for treating ESRD. Microchannel-based hemodialysis is one proposed option, already shown to have improved...
    Resource Type:
    Dissertation
    Full Text:
    ABSTRACT OF THE DISSERTATION OF Matthew Y. Coblyn for the degree of Doctor of Philosophy in Chemical

  • Coupled Compressive Sensing : Sequential Reinforcement Approach

    Creator:
    De Silva, Shashini A.
    Abstract:
    We consider multiple Compressive Sensing (CS) problems wherein the supports of signal vectors of CS problems are restricted to satisfy a collection of joint logical constraints, which we refer to as coupling constraints. We consider a case where the coupling constraints are encoded in a graph and present a sequential...
    Resource Type:
    Masters Thesis
    Full Text:
    . Title: Coupled Compressive Sensing : Sequential Reinforcement Approach Abstract approved: Jinsub Kim

  • Online product presentation and perceived trustworthiness : the moderating role of gender

    Creator:
    Marshall, Kerianne
    Abstract:
    E-commerce is growing each year, reaching 130.1 billion in 2008 (Internetretailer.com, 2009b). Retailers have turned their attention to the online channel to discover ways to stay competitive. Yet there is still limited research on online apparel retailing, especially in online product presentation. Thus, the purpose of this study was to...
    Resource Type:
    Masters Thesis
    Full Text:
    Gender. Abstract approved:________________________________________________________ Minjeong Kim E