OBJECTIVE: Pharmacokinetic interactions exist between combined
oral contraceptives and protease inhibitors (PI). However, such
information is lacking for progestin-only oral contraception. We
sought to define the steady-state pharmacokinetic interaction between
norethindrone (NET) and PI in HIV-infected women.
METHODS AND DESIGN: We conducted an open-label, prospective,
nonrandomized trial to characterize the...
This thesis presents the results of an investigation into the measured and modeled
mass balance of the Collier Glacier, a small (0.70 km²), valley glacier located in the
Oregon Cascade Range (44° 10' N, 121° 47' W). Here we present mass-balance
measurements conducted for the 2009 and 2010 balance years...
Climate model simulations and paleoclimate proxies are two tools that enable an understanding of the climate history of the Earth. When utilized together, they form a powerful paradigm for understanding past changes. Proxies are the only physical link to the past conditions on Earth, and models “fill in the gaps”...
Environmental DNA (eDNA) is an emerging biological monitoring tool that can aid in assessing the effects of forestry and forest manufacturing activities on biota. Monitoring taxa across broad spatial and temporal scales is necessary to ensure forest management and forest manufacturing activities meet their environmental goals of maintaining biodiversity. Our...
Irrigated agricultural production in sandy soils presents several unique challenges to growers, including naturally high permeability, low native water retention, as well as high rates of water drainage losses and leaching of chemicals to the shallow aquifers. This study is an initial investigation into water motion in the sandy agricultural...
Pesticides benefit agriculture by increasing crop yield, quality, and security. However, pesticides may inadvertently harm bees, which are valuable as pollinators. Thus, candidate pesticides in development pipelines must be assessed for toxicity to bees.
Leveraging a data set of 382 molecules with toxicity labels from honey bee exposure experiments, we...
This dissertation describes patterns in epiphytic macrolichen community composition, diversity, and biomass across various stand types in the Blue River watershed of western Oregon. It first examines the relative importance of ecological factors such as stand age, remnant tree retention, and topography to lichen communities in the landscape. It then...
The human intervertebral disc is a deceptively simple structure which plays an essential role in human movement. Even slight changes to the disc microenvironment can have far reaching consequences, particularly when these changes result in disc degeneration and herniation. Degeneration is increasingly tied to lower back pain; better understanding this...
Latinx youth in the US experience stark inequities in sexual and reproductive health, including rates of unplanned pregnancy and sexually transmitted infections. One promising way to reduce these inequities is to provide culturally centered, comprehensive sexual health education. However, such curricula are rarely offered to Latinx youth, in part because...
This research focuses on receiver architectures which enable better spectral eciency
by handling blockers in the same spectral range as the signal. The presence of
such blockers, without the use of blocker cancelling/ ltering techniques leads to gain
compression and hence, consequent performance degradation of receivers leading to
reduced spectrum...