Pactamycin, although putatively touted as a potent antitumor agent, has never been used as an anticancer drug due to its high cytotoxicity. In this study, we characterized the effects of two novel biosynthetically engineered analogs of pactamycin, de-6MSA-7-demethyl-7- deoxypactamycin (TM-025) and 7-demethyl-7-deoxypactamycin (TM-026), in head and neck squamous cell carcinoma...
In Heart of Darkness and The Good Soldier, Joseph Conrad and Ford Madox Ford employ the narrative subjectivity inherent in their Impressionist technique to provide insight into the often-irrational processes through which political and individual identities are constructed through narrative. Contrary to traditional readings of Impressionism as a strictly aesthetic...
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Molly
Jones
In Heart of Darkness and The Good Soldier, Joseph Conrad and Ford Madox Ford employ the narrative subjectivity inherent in their Impressionist technique to provide insight into the often-irrational processes through which political and individual identities are constructed through narrative. Contrary to traditional readings of Impressionism as a strictly aesthetic...
Gene expression is largely regulated by the binding of transcription factors to short sequences of DNA (transcription factor binding sites) to drive or repress transcription of an adjacent gene. Identifying the key transcription factor binding sites associated with a particular biological outcome provides an avenue for tailored transcriptional regulation in...
Gene regulation is a complex mechanism that controls the spatial and temporal expression of genes in a living cell. My dissertation studies focus on two problems. First, tissue-specific gene expression prediction from DNA sequence and chromatin state, and second, the accurate discovery of small over-represented regulatory circuits in gene regulatory...
Nonprofit organizations are feeling increased pressure to demonstrate their service’s impacts to their investors. Social return on investment is a tool that measures the social efficiency, or social return, of services by calculating a social return ratio. While social return on investment has seen increasing use by nonprofit organizations, a...
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Mercury and arsenic are known developmental toxicants and environmental exposures are ubiquitous worldwide from natural and anthropogenic sources. Prenatal exposure to both contaminants are independently associated with adverse perinatal health outcomes and latent disease risk that could be in part mediated by epigenetic reprogramming events. Fetal programming events involving DNA...
Evolve & Resequence (E&R) experiments subject laboratory populations to environments controlled by investigators, who then document the phenotypic and genomic changes that take place over many generations. These experiments provide powerful tools for testing of a wide variety of evolutionary questions, especially questions about the nature of adaptive traits. While...