We have previously shown that relative potency factors and DNA adduct measurements are inadequate for predicting carcinogenicity of certain polycyclic aromatic hydrocarbons (PAHs) and PAH mixtures, particularly those that function through alternate pathways or exhibit greater
promotional activity compared to benzo[a]pyrene (BaP). Therefore, we developed a pathway
based approach for...
In 2004 the National Toxicology Program published an article describing their intent to pursue toxicology testing and risk assessment practices solely reliant on high throughput in vitro datasets and in silico modeling for dose-response assessments. Support and contributions form regulatory agencies and a significant portion of the life sciences community...
The Gulf of Mexico Red Snapper IFQ Program (Program) was the first catch share management program implemented in the Gulf of Mexico. IFQ management was implemented to reduce overcapacity and eliminate the problems associated with derby style fishing. The Program was successful, the number of vessels harvesting red snapper decreased...
Catch share management programs are designed to reduce overcapacity in fisheries through trading as efficient harvesters buy out their less efficient counterparts. Numerous studies have looked at either the ex-ante potential of catch shares management to reduce overcapacity in a fishery or the ex-post effects of implementing such a program,...
During the first three years (2007-2009) of the Gulf of Mexico red snapper IFQ program most quota lease trades were local, involving fishers that lived in the same communities. In 2010, the red snapper quota lease market changed as more IFQ participants began trading quota with fishers from different regions...
Many of the tangible benefits of catch share programs (e.g., reducing overcapacity) are dependent on the trading of shares. Additional trading-related questions (such as whether landings will change port or be concentrated geographically) are also important to the overall evaluation of a fishery, but are often asked only during post-implementation...
Epidermal RNA samples from FVB/N mice treated with PAH standards and
environmental PAH mixtures were harvested and purified using Trizol extraction and
RNeasy mini prep kit purification. Epidermal RNA integrity was low (RIN mean 3.5),
indicating significant RNA degradation and the need to modify handling, collection, and
processing of skin...
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and
purification of dermal RNA from FVB/N mice
treated with environmental PAH mixtures
Andy Larkin
Epidermal RNA samples from FVB/N mice treated with PAH standards and
environmental PAH mixtures were harvested and purified using Trizol extraction and
RNeasy mini prep kit purification. Epidermal RNA integrity was low (RIN mean 3.5),
indicating significant RNA degradation and the need to modify handling, collection, and
processing of skin...
Full Text:
with environmental PAH mixtures
Andrew Larkina,b, Lisbeth K. Siddensb, Sharon K. Kruegerc, David E
Epidermal RNA samples from FVB/N mice treated with PAH standards and
environmental PAH mixtures were harvested and purified using Trizol extraction and
RNeasy mini prep kit purification. Epidermal RNA integrity was low (RIN mean 3.5),
indicating significant RNA degradation and the need to modify handling, collection, and
processing of skin...
The Florida spiny lobster trap certificate program (TCP) is one of the oldest U.S. fisheries programs involving tradable effort permits. Under the TCP, fishers must own a certificate (and pay an associated annual fee) for each trap used. The program was created in 1992 to address overcapitalization amid growing social...