A model (called MERLIN) is presented that can allow the resource manager to consider the combined effects of silvicultural treatments and their effect on expected logging production and costs. This integrated analysis takes place within the framework of personal computer software readily available to most managers. This integration is accomplished...
Epidermal RNA samples from FVB/N mice treated with PAH standards and environmental PAH mixtures were harvested and purified using Trizol extraction and RNeasy mini prep kit purification. Epidermal RNA integrity was low (RIN mean 3.5), indicating significant RNA degradation and the need to modify handling, collection, and processing of skin...
For many years brined cherry stocks for eastern maraschino cherry processors were almost entirely imported from Italy and France. Only small quantities were barreled on the Pacific Coast for local use. Today that situation is almost entirely reversed. With the aid of a protective tariff on brined and processed cherries...
Polycyclic aromatic hydrocarbons (PAHs) are present in the environment as complex mixtures with components that have diverse carcinogenic potencies and mostly unknown interactive effects. Non-additive PAH interactions have been observed in regulation of cytochrome P450 (CYP) gene expression in the CYP1 family. To better understand and predict biological effects of...
We have previously shown that relative potency factors and DNA adduct measurements are inadequate for predicting carcinogenicity of certain polycyclic aromatic hydrocarbons (PAHs) and PAH mixtures, particularly those that function through alternate pathways or exhibit greater
promotional activity compared to benzo[a]pyrene (BaP). Therefore, we developed a pathway
based approach for...
