Overtly non-toxic doses of organochlorine (OC) insecticides perturb lipid homeostasis
in mice and rats. To increase understanding of how chlordecone (CD), an OC
insecticide, modulates cholesterol (CH) homeostasis, we determined the effect of CD
pretreatment on the tissue and hepatic subcellular distribution of exogenous [¹⁴C]CH. Corn oil alone or CD...
Liver X receptor (LXR), farnesoid X receptor (FXR) and peroxisome
proliferator-activated receptor (PPAR) are adopted orphan nuclear receptors that
function as lipid sensors. These receptors respond to cellular lipid levels and
regulate the expression of target gene. Previously, it was demonstrated that low
doses of chlordecone (CD) pretreatment disturbed exogenous...
Pretreatment of male C57BL/6 mice with low doses of the persistent organochlorine
(OC) pesticide, chlordecone (CD), stimulated biliary excretion of exogenous CH up to 3-fold. Increased biliary excretion occurred without changes in hepatic ATP-binding
cassette transporter G8 (ABCG8) of the bile canaliculus or scavenger receptor class B
type I (SR-BI)...
Chlordecone belongs to the class of persistent organochlorine pesticides that are remarkably resistant to environmental degradation. Even though their use was banned in the United States in 1978, these compounds can still be detected in both humans and wildlife throughout the world. Previous work has shown that the pretreatment of...
Visual appeal of wood is as important as its
structural integrity in outdoor applications. Discoloration
and checking of wood favor the utilization of alternative
materials for outdoor cladding and decking. Lignin depolymerization
is one of the critical processes leading to
weathering. In the present paper, the potential of different
Polycyclic aromatic hydrocarbons (PAHs) are significant pollutants in aquatic environments. Many are carcinogenic and lead to DNA fragmentation and adduct formation in marine and freshwater organisms. Previous research demonstrates that rainbow trout (Oncorhynchus mykiss) compensate to long-term PAH dietary exposures and reduce the DNA damage.
The aim of this study...
Thermochemical water splitting cycles have been conceptualized and researched for over half a century, yet to this day none are commercially viable. The heavily studied Sulfur-Iodine cycle has been stalled in the early development stage due to a difficult HI-H₂O separation step and material compatibility issues. In an effort to...
The antimutagenic potency of wheat grain and berry extracts was studied in
vitro against several heterocyclic amines (HCAs) using the Salmonella
mutagenicity assay and the anticarcinogencity of wheat grain was studied in vivo
using the rat colonic aberrant crypt focus assay.
Wheat bran, which binds HCAs in vitro, as well...
Lymphomas and leukemias are the most common cancer in children and young
adults and in utero exposure to carcinogens may contribute to the etiology of these
cancers. A polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DBP), was
administered to pregnant mice (15 mg/Kg b.w., gavage) on gestation day 17. Significant
This study investigated complete reductive dechlorination of chlorinated
aliphatic hydrocarbons (CAHs) over a broad range of concentrations.
Tetrabutoxysilane (TBOS), as a slow-release anaerobic substrate, was studied for
enhanced reductive dechlorination of tetrachioroethylene (PCE) present as a dense
non-aqueous liquid (DNAPL). Four different site-mixed cultures were used in the