The lens dose equivalent (LDE) is a regulatory limit set to protect radiation workers. Current methods for estimating the LDE are specific to beam sources in a vacuum and require interpolating data from tables. A new set of deterministic equations for photon and electron point sources has been developed. These...
The objective of our study was to investigate the effect of selenium on
selenoprotein W. Western blot analysis indicated that selenoprotein W is present in
muscle, brain, testis and spleen of rat tissues. Tissue distribution of selenoprotein W
was not altered in rats fed various selenium levels. Among muscle, brain,...
Selenoprotein W (SeW) is a protein whose function is unknown, but potentially plays a vital role in calcium metabolism, as an indirect link has been established with white muscle disease (WMD). White muscle disease occurs in selenium deficient animals, and is characterized by the precipitation of calcium in muscle, leading...
The objective of this study was to further determine the distribution of
selenoprotein W (SeW) in tissues from rats and sheep fed different selenium levels and to
search for the possible functions of this protein. In the rat study a total of 28 rat tissues
were examined and SeW was...
Rat selenoprotein W (SeW) promoter activity was investigated using different concentrations of cadmium, copper, and zinc. Two fragments (404bp and 1265bp) of the SeW promoter, containing a single metal response element (MRE), were ligated into the multiple cloning site of a pGL3-Basic reporter plasmid. The constructs were transfected into cultured...
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2.(a) Activity of unmutated (N) and mutant (M) versions of 404bp
promoter constructs in 6-day