Forest harvest residues can be a cost-effective feedstock for a biorefinery, but the high
lignin content of forest residues is a major barrier for enzymatic sugar production. Sulfite
pretreatment to overcome strong recalcitrance of lignocelluloses (SPORL) was applied to a
Douglas-fir (Pseudotsuga menziesii (Mirb) Franco var. menziesii) forest residue in...
Pyridoxal phosphate is a coenzyme in about 50 known enzymatic
reactions. A simple and accurate method for the determination of
pyridoxal phosphate would be desirable because it could provide a
means to assess the nutritional status of vitamin B₆ in the human.
The cyanohydrin methods to determine pyridoxal phosphate appear...
Cancer is one of the leading causes of death in the U.S., and new approaches to control cancer are constantly sought. This dissertation is comprised of two parts: (i) improving the uptake and retention of gadolinium in tumors for potential gadoliniumneutron capture therapy (Gd-NCT) and (ii) integration of gemcitabine or...
State-of-the-art, high-resolution mass spectrometry techniques for acquisition of metabolomic and lipidomic data coupled with advanced computational methods provide new opportunities for interpreting large and complex datasets and comprehending the underlying biological processes of diseases. Both metabolomics and lipidomics strive to obtain comprehensive analyses of small molecules, i.e., metabolites and lipids,...
Cyclic nitramines are a class of compounds that include most of the commonly used explosives today. These are among the most common toxicants released into the environment as a result of human activity, generated on military ranges, battlefields, and production sites. Of these, hexahydro-1,3,5-trinitro-1,3,5- triazine (RDX) is of particular interest,...
The interaction of lecithin-cholesterol acyltransferase (LCAT) with apolipoprotein A-I (apoA-I) plays a critical role in highdensity lipoprotein (HDL) maturation.Wepreviously identified a highly solvent-exposed apoA-I loop domain (Leu¹⁵⁹–Leu¹⁷⁰) in nascent HDL, the so-called “solar flare” (SF) region, and proposed that it serves as an LCAT docking site (Wu, Z., Wagner, M....
Italian ryegrass (Lolium perenne spp. multiflorum) is a common weed management problem in turfgrasses, cereals and non-crop areas in the United States. In Oregon, the number of populations with multiple-resistance continues to increase. To manage these resistant populations, the resistance patterns must be determined. In this study, five Italian ryegrass...
Gadusol is a UV-B-absorbent compound found in fish and other marine organisms where it is presumed to play a role as a sunscreen and antioxidant. In light of commercial potential as a replacement for problematic synthetic sunscreens, a process to produce recombinant gadusol in the yeast Saccharomcyces cerevisiae was investigated....
Vibrio cholerae is autochthonous to various aquatic niches and is the etiological agent of the life-threatening diarrheal disease
cholera. The persistence of V. cholerae in natural habitats is a crucial factor in the epidemiology of cholera. In contrast to the
well-studied V. cholerae-chitin connection, scarce information is available about the...