Irradiation of a tryptamine linked through its side-chain nitrogen to an alkylidene malonate residue results in an intramolecular [2 + 2] cycloaddition to the indole 2,3-double bond. The resultant cyclobutane undergoes spontaneous retro-Mannich fission to produce a spiro[indoline-3,3-pyrrolenine] with relative configuration defined by the orientation of substituents in the transient...
Culture, thought worldview and language have been
discussed for a long time in different fields from various
perspectives. However, the basis of this study is the view
of language as both the product and producer of people just
as people are the producer and product of language. Each
language requires...
We present two facile time-of-flight (TOF) methods of detecting superfluid helium droplets and droplets with neutral dopants. Without an electron gun and with only a heated filament and pulsed electrodes, the electron impact ionization TOF mass spectrometer can resolve ionized helium clusters such as He₂ ⁺ and He₄ ⁺, which...
Only two genome-wide significant loci associated with longevity have been identified so far, probably because of insufficient sample sizes of centenarians, whose genomes may harbor genetic variants associated with health and longevity. Here we report a genome-wide association study (GWAS) of Han Chinese with a sample size 2.7 times the...
Full Text:
, Mingbang Wang
3
, Ting Ni
7
, YangLi
8
, Han Yan
8
, Jin-Pei Zhang
8
, Chun Song
8
,
Li-Qing Chi
8
Only two genome-wide significant loci associated with longevity have been identified so far, probably because of insufficient sample sizes of centenarians, whose genomes may harbor genetic variants associated with health and longevity. Here we report a genome-wide association study (GWAS) of Han Chinese with a sample size 2.7 times the...
Full Text:
Chen1,6,
Hanshi Xu3, Mingbang Wang3, Ting Ni7, Yang Li8, Han Yan8, Jin-Pei Zhang8, Chun Song8, Li-
Qing
Only two genome-wide significant loci associated with longevity have been identified so far, probably because of insufficient sample sizes of centenarians, whose genomes may harbor genetic variants associated with health and longevity. Here we report a genome-wide association study (GWAS) of Han Chinese with a sample size 2.7 times the...
Mud volcanoes (MVs) are considered as important methane (CH₄) sources for the
atmosphere; gas is not only released from macroseepage, i.e., from craters and visible gas bubbling
manifestations, but also from invisible and pervasive exhalation from the ground, named miniseepage.
CH₄ flux related to miniseepage was measured only in a...
Phytophthora pathogens secrete an array of specific effector proteins to manipulate host innate immunity to promote pathogen colonization. However, little is known about the host targets of effectors and the specific mechanisms by which effectors increase susceptibility. Here we report that the soybean pathogen Phytophthora sojae uses an essential effector...
Phytophthora pathogens secrete an array of specific effector proteins to manipulate host innate immunity to promote pathogen colonization. However, little is known about the host targets of effectors and the specific mechanisms by which effectors increase susceptibility. Here we report that the soybean pathogen Phytophthora sojae uses an essential effector...