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- Creator:
- Liu, Xiao
- Abstract:
- Bcl11b (B-cell lymphoma/leukemia 11b), also known as Ctip2 (Chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2), is a C2H2 zinc finger transcriptional regulatory protein, which is an essential protein for post-natal life in the mouse and plays crucial roles in the development, and presumably function, of several organ systems,...
- Resource Type:
- Masters Thesis
- Full Text:
- ABSTRACT OF THE THESIS OF Xiao Liu for the degree of Master of Science in Pharmacy presented on June
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- Creator:
- Kidd, Jeffrey M., Sharpton, Thomas J., Bobo, Dean, Norman, Paul J., Martin, Alicia R., Carpenter, Meredith L., Sikora, Martin, Gignoux, Christopher R., Nemat-Gorgani, Neda, Adams, Alexandra, Guadalupe, Moraima, Guo, Xiaosen, Feng, Qiang, Li, Yingrui, Liu, Xiao, Parham, Peter, Hoal, Eileen G., Feldman, Marcus W., Pollard, Katherine S., Wall, Jeffrey D., Bustamante, Carlos D., and Henn, Brenna M.
- Abstract:
- BACKGROUND: Targeted capture of genomic regions reduces sequencing cost while generating higher coverage by allowing biomedical researchers to focus on specific loci of interest, such as exons. Targeted capture also has the potential to facilitate the generation of genomic data from DNA collected via saliva or buccal cells. DNA samples...
- Full Text:
- , Xiaosen Guo9, Qiang Feng9, Yingrui Li9, Xiao Liu9, Peter Parham6, Eileen G Hoal10, Marcus W Feldman11
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- Creator:
- Kidd, Jeffrey M., Sharpton, Thomas J., Bobo, Dean, Norman, Paul J., Martin, Alicia R., Carpenter, Meredith L., Sikora, Martin, Gignoux, Christopher R., Nemat-Gorgani, Neda, Adams, Alexandra, Guadalupe, Moraima, Guo, Xiaosen, Feng, Qiang, Li, Yingrui, Liu, Xiao, Parham, Peter, Hoal, Eileen G., Feldman, Marcus W., Pollard, Katherine S., Wall, Jeffrey D., Bustamante, Carlos D., and Henn, Brenna M.
- Abstract:
- BACKGROUND: Targeted capture of genomic regions reduces sequencing cost while generating higher coverage by allowing biomedical researchers to focus on specific loci of interest, such as exons. Targeted capture also has the potential to facilitate the generation of genomic data from DNA collected via saliva or buccal cells. DNA samples...
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- Creator:
- Kidd, Jeffrey M., Sharpton, Thomas J., Bobo, Dean, Norman, Paul J., Martin, Alicia R., Carpenter, Meredith L., Sikora, Martin, Gignoux, Christopher R., Nemat-Gorgani, Neda, Adams, Alexandra, Guadalupe, Moraima, Guo, Xiaosen, Feng, Qiang, Li, Yingrui, Liu, Xiao, Parham, Peter, Hoal, Eileen G., Feldman, Marcus W., Pollard, Katherine S., Wall, Jeffrey D., Bustamante, Carlos D., and Henn, Brenna M.
- Abstract:
- BACKGROUND: Targeted capture of genomic regions reduces sequencing cost while generating higher coverage by allowing biomedical researchers to focus on specific loci of interest, such as exons. Targeted capture also has the potential to facilitate the generation of genomic data from DNA collected via saliva or buccal cells. DNA samples...
- Full Text:
- Guadalupe8, Xiaosen Guo9, Qiang Feng9, Yingrui Li9, Xiao Liu9, Peter Parham6, Eileen G. Hoal10, Marcus W
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- Creator:
- Kidd, Jeffrey M., Sharpton, Thomas J., Bobo, Dean, Norman, Paul J., Martin, Alicia R., Carpenter, Meredith L., Sikora, Martin, Gignoux, Christopher R., Nemat-Gorgani, Neda, Adams, Alexandra, Guadalupe, Moraima, Guo, Xiaosen, Feng, Qiang, Li, Yingrui, Liu, Xiao, Parham, Peter, Hoal, Eileen G., Feldman, Marcus W., Pollard, Katherine S., Wall, Jeffrey D., Bustamante, Carlos D., and Henn, Brenna M.
- Abstract:
- BACKGROUND: Targeted capture of genomic regions reduces sequencing cost while generating higher coverage by allowing biomedical researchers to focus on specific loci of interest, such as exons. Targeted capture also has the potential to facilitate the generation of genomic data from DNA collected via saliva or buccal cells. DNA samples...
- Resource Type:
- Article
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- Creator:
- Liu, Wei, Zhang, Bo, Zhang, Zhiwei, and Zhou, Xiao-Hua
- Abstract:
- While the experimental Alzheimer's drugs recently developed by pharmaceutical companies failed to stop the progression of Alzheimer's disease, clinicians strive to seek clues on how the patients would be when they visit back next year, based upon the patients' current clinical and neuropathologic diagnosis results. This is related to how...
- Resource Type:
- Article
- Full Text:
- Alzheimer’s Disease Wei Liu1, Bo Zhang2*, Zhiwei Zhang3, Xiao-Hua Zhou4 1 Department of Mathematics, Harbin
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- Creator:
- Xiao, Jun-An, Liu, Qi, Ren, Ji-Wei, Liu, Jian, Carter, Rich G., Chen, Xiao-Qing, and Yang, Hua
- Abstract:
- An enantioselective 1,3-dipolar cycloaddition of 2-cyclo-hexene-1-one and azomethine ylide generated in situ from isatin and amino ester was developed by employing proline sulfonamide as the catalyst. Consequently, novel polycyclic spirooxindole scaffolds with three contiguous stereocenters were prepared in high yield (up to 95%) with excellent diastereo- (> 20:1 dr) and...
- Resource Type:
- Article
- Full Text:
- Cycloaddition of 2-Cyclohexenone Catalyzed by Proline-Sulfonamide Xiao, J. A., Liu, Q., Ren, J. W., Liu, J
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- Creator:
- Zeng, Yi, Nie, Chao, Min, Junxia, Liu, Xiaomin, Li, Mengmeng, Chen, Huashuai, Xu, Hanshi, Wang, Mingbang, Ni, Ting, Li, Yang, Yan, Han, Zhang, Jin-Pei, Song, Chun, Chi, Li-Qing, Wang, Han-Ming, Dong, Jie, Zheng, Gu-Yan, Lin, Li, Qian, Feng, Qi, Yanwei, Liu, Xiao, Cao, Hongzhi, Wang, Yinghao, Zhang, Lijuan, Li, Zhaochun, Zhou, Yufeng, Wang, Yan, Lu, Jiehua, Li, Jianxin, Qi, Ming, Bolund, Lars, Yashin, Anatoliy, Land, Kenneth C., Gregory, Simon, Yang, Ze, Gottschalk, William, Tao, Wei, Wang, Jian, Wang, Jun, Xu, Xun, Bae, Harold, Nygaard, Marianne, Christiansen, Lene, Christensen, Kaare, Franceschi, Claudio, Lutz, Michael W., Gu, Jun, Tan, Qihua, Perls, Thomas, Sebastiani, Paola, Deelen, Joris, Slagboom, Eline, Hauser, Elizabeth, Xu, Huji, Tian, Xiao-Li, Yang, Huanming, and Vaupel, James W.
- Abstract:
- Only two genome-wide significant loci associated with longevity have been identified so far, probably because of insufficient sample sizes of centenarians, whose genomes may harbor genetic variants associated with health and longevity. Here we report a genome-wide association study (GWAS) of Han Chinese with a sample size 2.7 times the...
- Full Text:
- ,# * , Chao Nie 3,# , Junxia Min 4,# ,Xiaomin Liu 3,# , Mengmeng Li 5 , Huashuai Chen 1,6 , Hanshi Xu 3
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- Creator:
- Zeng, Yi, Nie, Chao, Min, Junxia, Liu, Xiaomin, Li, Mengmeng, Chen, Huashuai, Xu, Hanshi, Wang, Mingbang, Ni, Ting, Li, Yang, Yan, Han, Zhang, Jin-Pei, Song, Chun, Chi, Li-Qing, Wang, Han-Ming, Dong, Jie, Zheng, Gu-Yan, Lin, Li, Qian, Feng, Qi, Yanwei, Liu, Xiao, Cao, Hongzhi, Wang, Yinghao, Zhang, Lijuan, Li, Zhaochun, Zhou, Yufeng, Wang, Yan, Lu, Jiehua, Li, Jianxin, Qi, Ming, Bolund, Lars, Yashin, Anatoliy, Land, Kenneth C., Gregory, Simon, Yang, Ze, Gottschalk, William, Tao, Wei, Wang, Jian, Wang, Jun, Xu, Xun, Bae, Harold, Nygaard, Marianne, Christiansen, Lene, Christensen, Kaare, Franceschi, Claudio, Lutz, Michael W., Gu, Jun, Tan, Qihua, Perls, Thomas, Sebastiani, Paola, Deelen, Joris, Slagboom, Eline, Hauser, Elizabeth, Xu, Huji, Tian, Xiao-Li, Yang, Huanming, and Vaupel, James W.
- Abstract:
- Only two genome-wide significant loci associated with longevity have been identified so far, probably because of insufficient sample sizes of centenarians, whose genomes may harbor genetic variants associated with health and longevity. Here we report a genome-wide association study (GWAS) of Han Chinese with a sample size 2.7 times the...
- Full Text:
- Chi8, Han-Ming Wang8, Jie Dong8, Gu-Yan Zheng8, Li Lin5, Feng Qian5, Yanwei Qi3,9, Xiao Liu3, Hongzhi
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- Creator:
- Zeng, Yi, Nie, Chao, Min, Junxia, Liu, Xiaomin, Li, Mengmeng, Chen, Huashuai, Xu, Hanshi, Wang, Mingbang, Ni, Ting, Li, Yang, Yan, Han, Zhang, Jin-Pei, Song, Chun, Chi, Li-Qing, Wang, Han-Ming, Dong, Jie, Zheng, Gu-Yan, Lin, Li, Qian, Feng, Qi, Yanwei, Liu, Xiao, Cao, Hongzhi, Wang, Yinghao, Zhang, Lijuan, Li, Zhaochun, Zhou, Yufeng, Wang, Yan, Lu, Jiehua, Li, Jianxin, Qi, Ming, Bolund, Lars, Yashin, Anatoliy, Land, Kenneth C., Gregory, Simon, Yang, Ze, Gottschalk, William, Tao, Wei, Wang, Jian, Wang, Jun, Xu, Xun, Bae, Harold, Nygaard, Marianne, Christiansen, Lene, Christensen, Kaare, Franceschi, Claudio, Lutz, Michael W., Gu, Jun, Tan, Qihua, Perls, Thomas, Sebastiani, Paola, Deelen, Joris, Slagboom, Eline, Hauser, Elizabeth, Xu, Huji, Tian, Xiao-Li, Yang, Huanming, and Vaupel, James W.
- Abstract:
- Only two genome-wide significant loci associated with longevity have been identified so far, probably because of insufficient sample sizes of centenarians, whose genomes may harbor genetic variants associated with health and longevity. Here we report a genome-wide association study (GWAS) of Han Chinese with a sample size 2.7 times the...
- Resource Type:
- Article