Index Catalog // ScholarsArchive@OSU

Start Over

Filtering by: Committee Member Lowry, Malcom

Immunomodulatory Actions of Bovine Whey Protein Isolates, Glycomacropeptide, and Their Digests: Insights from Macrophage and Human Studies

Creator:

Olsen, Wyatt

Abstract:

Whey protein isolate (WPI) and glycomacropeptide (GMP) have shown potential immunomodulatory properties. In this study, we investigated their effects on pro-inflammatory cytokine secretion using both in vitro and in vivo models. In LPS-stimulated THP-1-derived macrophages, digested WPI and GMP reduced cytokine expression, while whole GMP increased secretion. The in human...

Resource Type:

Masters Thesis
The role of leptin in normal and pathological bone resorption

Creator:

Philbrick, Kenneth Alan

Abstract:

Particles generated from wear of prosthesis joint bearing surfaces induce inflammation and promote pathological periprosthetic osteoclast-mediated bone resorption (osteolysis). Obesity increases the risk of prosthesis failure. However, despite being morbidly obese, leptin-deficient ob/ob mice are resistant to osteolysis. These findings suggest that leptin exerts effects that act to increase particle-induced...

Resource Type:

Dissertation