Index Catalog // ScholarsArchive@OSU

The analysis of kisspeptin neuronal exosomes and their effects on neuronal plasticity of downstream gonadotropin-releasing hormone expressing neurons

Creator:: Ewton, Jessica
Abstract:: Gonadotropin-releasing hormone (GnRH) neurons are able to trigger the release of luteinizing hormone and follicle-stimulating hormone which control the maturation of oocytes and ovulation which is vital for reproduction. They are the most downstream neurons that project to the median eminence into the pituitary portal where they release GnRH. Modulation...
Resource Type:: Honors College Thesis
Full Text:: Biomedical Sciences Jennifer Johns, Committee Member, representing Clinical Pathology Kathy Magnusson

Expression of Gonadotropin-Releasing Hormone Receptor in Kisspeptin Neurons: A Potential Model For Positive Feedback

Creator:: Rayzman, Noa
Abstract:: Estradiol (E2) plays a role in positive and negative feedback mechanisms of the hypothalamic-pituitary-gonadal (HPG) axis in female mammals. These mechanisms are regulated by two different populations of kisspeptin (KP)-producing neurons: anteroventral periventricular (AVPV) neurons, which are stimulated by E2, and arcuate (arc) neurons, which are inhibited by E2. AVPV...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Kathy Magnusson, Committee Member, representing Neuroscience

The Analysis of Kisspeptin Neuronal Exosomes and their Effects in the Periphery at the Level of the Bone

Creator:: James, Teagan
Abstract:: Estrogen (E2) is essential for multiple physiological effects in females, ensuring maximum reproductive fitness and maintaining skeletal homeostasis. E2 has been shown to stimulate cancellous bone formation via activation of estrogen receptor alpha (ERα), an effect widely accepted to be mediated directly at bone. A recent landmark study by Herber...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Kathy Magnusson, Committee Member, representing Neuroscience

The Role of Nrf2 in Brain Cellular Senescence

Creator:: Ross, Grace K.
Abstract:: Aging is a major risk factor for the deterioration of biochemical pathways that lead to many chronic neurodegenerative disorders (i.e. Parkinson’s and Alzheimer's Disease). Cellular senescence is a hallmark of aging, a condition characterized by stable growth arrest resulting in a cell that no longer divides, but is metabolically active....
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Kathy Magnusson, Committee Member, representing Biomedical Sciences, College of Veterinary

Investigating the Interplay of Age, Zinc Status, and the Gut Microbiome on Gut Health

Creator:: Vasudevan, Anusha
Abstract:: Zinc is an important micronutrient involved in many cellular processes, including those part of immune function; however, about 15% of the US population is at risk for marginal zinc deficiency. This can lead to immune system complications including the generation of inflammatory cytokines. Aging is another factor that worsens the...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Kathy Magnusson, Committee Member, representing Biomedical Sciences

Generating Communication -Deficient and -Intensified Neurons to Determine Effects on Multicellular Information Networks

Creator:: Starman, Alia
Abstract:: Multicellular coordination in response to environmental stimuli is essential in biology, and this coordination is often achieved by a division of labor to establish leaders and followers in a cell population. This is called emergent leadership, but how a cell adopts its role and effectively exchanges information with peers is...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Kathy Magnusson, Committee Member, representing Neuroscience

Low-Dose X-Ray Radiation Effects On the Proteomic Profiles of Hippocampus, Cortex, and Cerebellum of Contextual Fear Conditioning and Novel Object Recognition Trained Mice

Creator:: Koluda, Rony
Abstract:: Radiation exposure to the brain can occur from a variety of events, including space missions, nuclear accidents, and clinical treatments. The effects of high dose radiation are well studied, but those of lower dosage are more elusive. Decline of memory and cognition is observed in patients exposed to low dose...
Resource Type:: Masters Thesis
Full Text:: , and Dr. Kathy Magnusson, for their unwavering support in the completion of my degree despite the

The Effect of Zinc Status and Age on Liver Health in Mice

Creator:: Braun, Kendra N.
Abstract:: Age-related diseases have been associated with chronic inflammation and impaired immune response, one of the hallmarks of aging. Aging individuals also have a higher susceptibility to zinc deficiency. The effects of zinc deficiency share many commonalities with the effects of aging on the immune system and zinc deficiency may be...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Kathy R. Magnusson, Committee Member, representing Biomedical Sciences

Investigating the Impact of the Gut Microbiota on Rodent Behavior and their Interaction with Enteroendocrine Cells

Creator:: Singla, Priyanka
Abstract:: Gut-brain communication consists of bidirectional routes between cognitive centers of the brain and peripheral intestines. This bidirectional communication is the result of the interplay between enteroendocrine cells (EECs), enteric nervous system, central nervous system, the vagus nerve, and our microbiota. Multiple studies have associated gut microbial dysbiosis with neurological disorders...
Resource Type:: Masters Thesis
Full Text:: for this project, and Prof. Kathy Magnusson for helping us with the nodose ganglion dissection. Also

The Role of Cellular Senescence in the Development of Alzheimer's Disease

Creator:: Riordan, Ruben
Abstract:: Alzheimer’s Disease (AD) is a neurodegenerative pathology currently affecting nearly 44 million individuals worldwide, yet there are not currently any effective treatments or preventions for AD despite the rapid development in our understanding of the disease over the last four decades. The medical and sanitary innovations of the last century...
Resource Type:: Dissertation
Full Text:: committee members Dr. Maria Clara Franco, Dr. Kathy Magnusson, Dr. Colin Johnson, and Dr. Kevin Gable

ScholarsArchive@OSU

The analysis of kisspeptin neuronal exosomes and their effects on neuronal plasticity of downstream gonadotropin-releasing hormone expressing neurons

Expression of Gonadotropin-Releasing Hormone Receptor in Kisspeptin Neurons: A Potential Model For Positive Feedback

The Analysis of Kisspeptin Neuronal Exosomes and their Effects in the Periphery at the Level of the Bone

The Role of Nrf2 in Brain Cellular Senescence

Investigating the Interplay of Age, Zinc Status, and the Gut Microbiome on Gut Health

Generating Communication -Deficient and -Intensified Neurons to Determine Effects on Multicellular Information Networks

Low-Dose X-Ray Radiation Effects On the Proteomic Profiles of Hippocampus, Cortex, and Cerebellum of Contextual Fear Conditioning and Novel Object Recognition Trained Mice

The Effect of Zinc Status and Age on Liver Health in Mice

Investigating the Impact of the Gut Microbiota on Rodent Behavior and their Interaction with Enteroendocrine Cells

The Role of Cellular Senescence in the Development of Alzheimer's Disease

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